查詢結果分析
相關文獻
- Beneficial Effects of Tetramethylpyrazine, an Active Constituent of Chinese Herbs, on Rats with Endotoxemia
- 導管引起之敗血症
- 敗血症(Sepsis)致病機轉及治療
- 敗血性休克的致病機轉和治療之探討:生理、生化、藥物和藥理的角度
- 氣腫性腎盂腎炎--10病例分析和文獻回顧
- 原發性海洋弧菌敗血症
- Community-Acquired Pseudomonas Aeruginosa Bacteremia and Sepsis in Previously Healthy Infants
- Aeromonas Sepsis in Severe Burn Patients
- Hypothermia Predisposing to Pseudomonas Putida Sepsis in a Child with Panhypopituitarism
- 新生兒細菌性敗血症
頁籤選單縮合
題名 | Beneficial Effects of Tetramethylpyrazine, an Active Constituent of Chinese Herbs, on Rats with Endotoxemia=Tetramethylpyrazine具防禦敗血症之形成 |
---|---|
作者 | 廖美惠; 吳錦楨; 顏茂雄; Liao, Mei-hui; Wu, Chin-chen; Yen, Mao-hsiung; |
期刊 | 康寧學報 |
出版日期 | 19981200 |
卷期 | 1:1 1998.12[民87.12] |
頁次 | 頁89-112 |
分類號 | 418.1 |
語文 | eng |
關鍵詞 | 敗血症; Tetramethylpyrazine; |
中文摘要 | Tetramethylpyrazine(中藥川芎的一主成份),也是一種phosphodiesterase抑 制劑, 長期在中國大陸被用來改善心血管疾病。 此研究動機在探討 tetramethylpyrazine 對內毒素在大鼠所引起的低血壓、血管低反應性和腫瘤壞死因子及一氧化氮的釋出之影響。 結果顯示, 大鼠經內毒素( 10 mg ╱ kg,i.v. )注射後會引起低血壓和心跳加快的現象 , tetramethylpyrazine ( 10 mg ╱ kg,i.p. )可使血壓回升但卻使心跳有更加快的趨 勢。 內毒素也會引起對 norepinephrine ( NE )的升壓(活體;1 mg ╱ kg,i.v. )和 收縮(離體;1 mM )反應變差,而大鼠在經 tetramethylpyrazine 預處理後,皆可部份改 善此血管低反應性的現象。內毒素會導致血中腫瘤壞死因子及一氧化氮濃度的上升,而此作 用可被 tetramethylpyrazine 所部份拮抗。 另外,tetramethylpyrazine 也可部份改善內 毒素所引發的早期低血壓作用, 由 acetylcholine ( ACh; 1 mM )的舒張反應證實 tetramethylpyrazine 並不影響內皮型一氧化氮合成酵素的活性(因 ACh 的舒張反應不受 tetramethylpyrazine 的影響)。因此,tetramethylpyrazine 改善內毒素所引起的低血壓 作用可能是經由減少循環因子(活化內皮型一氧化氮合成酵素)和腫瘤壞死因子的釋出進而 阻斷誘導型一氧化氮合成酵素的生成所致。 |
英文摘要 | Tetramethylpyrazine, an inhibitor of phosphodiesterase, has been widely used for treatment of cardiovascular diseases in China. Here, we investigate the effects of tetramethylpyrazine on hypotension, vascular hyporeactivity to norepinephrine (NE), release of tumor necrosis factor- α (TNF α ) and nitric oxide (NO) in a rat model of circulatory shock induced by bacterial endotoxin (E. coli lipopolysaccharide, LPS). Male Wistar-Kyoto rats were anesthetized and instrumented for the measurement of mean arterial pressure (MAP) and heart rate (HR). Injection of LPS (10 mg/kg, i.v.) resulted in a fall in MAP and an increase of HR. In contrast, animals pretreated with tetramethylpyrazine (10 mg/kg, i.p. at 30 min prior to LPS) maintained a significantly higher MAP, but tachycardia was further enhanced at 60 min and 120 min when compared to rats given only LPS (LPS-rats). The pressor effect of NE (1 μ g/kg, i.v.) was also significantly reduced after treatment of rats with LPS. Similarly, the thoracic aorta obtained from rats after in vivo studies showed a significant reduction in the contractile responses elicited by NE (1 μ M). Pretreatment of LPS-rats with tetramethylpyrazine partially, but significantly, prevented this LPS-induced hyporeactivity to NE in vivo and ex vivo. The injection of LPS resulted in a significant increase in the plasma TNF α level at 60 min, whereas the effect of LPS on the plasma nitrate (an indicator of NO formation) level increased in a time-dependent manner. This increment of both TNFa and nitrate levels induced by LPS was significantly reduced in LPS-rats pretreated with tetramethylpyrazine. The early hypotension caused by LPS was slightly, but significantly, prevented by pretreatment with tetramethylpyrazine, suggesting that tetramethylpyrazine affects the endothelial constitutive NOS (eNOS). This was examined by the effect of tetramethylpyrazine on acetylcholine (ACh, 1 μ M)-induced relaxation in rats treated with tetramethylpyrazine for 4 h. However, tetramethylpyrazine had no significant effects on the ACh-induced relaxation, indicating that tetramwthylpyrazine does not affect the activity of eNOS. Thus, tetramethylpyrazine attenuates the early hypotension and the delayed circulatory failure caused by endotoxin in the rat. These effects may be due to inhibition of the release of circulation factors and TNF α, which usually reveal synergism upon the induction of iNOS. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。