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題 名 | The Role of Endothelin-1 in Binswanger's Disease=內皮素-1在Binswanger氏病中的作用 |
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作 者 | 陳春富; 郭述蘇; 賈海燕; 戴建溪; 薛慎伍; | 書刊名 | 中華醫學雜誌 |
卷 期 | 58:3 1996.09[民85.09] |
頁 次 | 頁151-155 |
分類號 | 415.92 |
關鍵詞 | 動脈硬化; Binswanger型白質腦病; 痴呆; 內皮素-1; Binswanger's encephalopathy; Dementia; Endothelin-1; |
語 文 | 英文(English) |
中文摘要 | 背景 神經系統存在內皮素-1,急性中風患者血漿內皮素-1含量升高。 本研究經由測定Binswanger病患者血漿內皮素-1含量的變化,探討內皮素與該 病的關係。 方法 採用放射免疫法測定31例Binswanger氏病患者及三個對照組血漿內皮 素-1的含量,內頸靜脈與肘前靜脈內皮素-1含量的比值作為反應腦循環內內皮 素-1水平的指標。 結果 Binswanger氏病組及中風對照組內皮素-1比值均明顯提高,前者比後者 比值提高更為多見。Binswanger氏病患者內皮素-1比值與長谷川智力量表測試 評分呈負相關。 結論 血管舒縮因子異常在Binswanger氏病中起著一定的作用,內皮素-1可能 參與了該病的發病機制。 |
英文摘要 | Background. Endothelin-1 is known to exist in the nervous system. A notable increase of plasma endothelin-1 is associated with acute stroke. This study was designed to measure plasma endothelin-1 levels in Binswanger's disease and explore the relationship between endothelin-1 and this disorder. Methods. Plasma levels of endothelin-1 were examined by radioimmunoassay in 31 patients with Binswanger's disease and in three groups of control subjects. The ratio of the plasma concentration of endothelin-1 in the internal jugular vein to that in the antecubital vein was calculated as an indicator of endothelin-1 level in cerebral circulation. Results. Endothelin-1 ratio elevation was seen more often in patients with Binswanger's disease than in acute stroke patients. Endithelin-1 ratios were significantly negatively correlated with Hasegawa's Dementia Scale scores in subjects with Binswanger's disease. Conclusions. Abnormalities in vasoactive factors may make an important contribution to the pathophysiology of Binswanger's disease. Endothelin-1 might be involved in the pathogenesis of this illness. |
本系統中英文摘要資訊取自各篇刊載內容。