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題名 | Effect of Ethanol on NMDA-Induced Neuronal Injury in Cortical Neuronal-Astroglial Cocultures=酒精對混合培養的大腦皮質神經細胞和星狀膠原細胞的影響 |
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作者 | 齊淑英; 張佐文; 林天南; 白慈玲; 郭典穎; | 書刊名 | 慈濟醫學 |
卷期 | 7:3 1995.09[民84.09] |
頁次 | 頁153-158 |
分類號 | 364.67911 |
關鍵詞 | 乙醇; N-甲基-D-天冬胺酸; 興奮性毒性; 星狀膠原細胞; 大腦皮質神經細胞; Ethanol; NMDA; Excitotoxicity; Astrocytes; Cortical neuron; |
語文 | 英文(English) |
中文摘要 | 在培養的大腦皮質神經細胞,乙醇保護神經細胞對抗NMDA興奮性毒性 的效果仍有爭論。我們發現:在富含星狀膠原細胞的培養大腦皮質神經細胞(體內 典型構造),事先給與乙醇(10-100mM,30 min)不能防止NMDA神經毒性 (60-500 uM,5-30min)所引起神經的死亡。評估神經的死亡,是採用相位差顯微鏡和培養液 中乳酸去氫酵素的釋放。此結果建議 :乙醇抑制NMDA神經毒性的能力,可能被 乙醇對膠原細胞的作用所抵消。所以,乙醇可能對由NMDA引起的腦傷沒有好 處。(慈濟醫學1995;7:153-158) |
英文摘要 | The neuroprotective effect of ethanol on N-methyl-D-aspartate (NMDA) excitotoxicity incortical cultures has been controversial. We show that application of ethanol (10-100 mM) onastrocyte-rich cortical cultures, typical structure in vivo, dose not prevent the neuronal death inducedby NMDA toxicity (60-500 uM, 5-30 min), assessed by phase-contrast microscopy and release oflactatedehydrogenase into medium. The results suggest that the ability of ethanol inhibitingNMDA neurotoxicity may be counter balanced by its actions on astrocytes. Therefore, ethanol may notbe beneficial to NMDA mediated brain injury.(Tzu Chi Med J 1995; 7: 153-158) |
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