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題名 | Pyrimethamine對大鼠胚胎致畸形性之研究 |
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作者 | 郭宗甫; 劉朝鑫; | 書刊名 | 國立臺灣大學農學院研究報告 |
卷期 | 34:4 1994.12[民83.12] |
頁次 | 頁305-334 |
分類號 | 437.23 |
關鍵詞 | 大鼠; 胚胎; 畸形; 致畸形劑量; Pyrimethamine; Rat; Embryo; Teratogenecity; Teratogen dosage; |
語文 | 中文(Chinese) |
中文摘要 | Pyrimethamine(PY)對於大鼠胚胎致害之危險期,以懷孕第8天至第11天時 危害最大,是最危險期。PY對大鼠胚胎之致畸形性作用,在懷孕第8天起連續投 藥4天,給與0.5mgPY/Kg B.W.時,沒有引起任何毒性作用:1mgPY/Kg B.W.(含)以 上時除了引起畸胎外,死亡和被吸收胚胎數目亦會顯著增加:2mgPY/Kg B.w.(含) 以上時除了引起畸胎,死亡和被吸收胚胎數目顯著增加外,存活胎仔平均體重會 顯著或極顯著下降。達8mgPY/KR B.W.時則引起全部鼠胚之被吸收。 畸胎的形態有裂顎,上唇裂、上頷裂,內臟外露,顱骨缺損,腦膨出,腦脊髓膨 出,水腦,短肢,鼻中隔筠曲,凸眼、獨眼,無眼,小眼,眼異位,嗅幹萎縮, 皮下瘀斑性出血等。從懷孕第8天起至第11天止連續口服4天,PY引起百分之五十 致大鼠胚胎死亡和吸收的劑量是4.20mgPY/Kg B.W.,引起百分之五十致大鼠畸胎 的劑量是2.18mgPY/Kg B.W.。 |
英文摘要 | These studies used Sprague Dawley rats as experimental animalsto achieve the following aims. 1) to explore the critical period of Pyrimethamine [PY] to the rat fetus; 2) to explore the maximal and minimal disastrous dosage of PY to the fetus and the circumstanceof teratogenicity ; 3) to explore the Lethal Dosage fifty [LD50] of PYto the rat embryos and resorptive dosage; 4) to explore the PYdosage which can cause 50 of fetus differentiated anormalies; Themost critical period of PY to the rat embryos is during the 8th to11th day of pregnancy. The teratogenicity of PY to the rat embryos is as follows: Fromthe 8th day of prenancy, continuously given 0.5mgPY/Kg B. W. forfour days, no toxic effect is detected;given lmgPY/Kg B. W. or above,besides anormalies, death and resorptive embryos increasedsignificantly; given 2 mgPY/Kg B. W., besides anormalies, death andresorptive embryos increased significantly, the average body weightof alive fetus significantly or more significantly reduced; given8mgPY/Kg B. W., all embryos were resorbed. The major malformations are cleft palate, cleft upper lip and jaw,eventration of the abdominal viscera, cranical defect, encephalocele,encephalomeningocele, hydrocephalus, micromelia, bend nasal septum,ophthalmoptosis, cyclopia, ophthalmosteresis, microphthalmia,ectopiaophthalmus, olfactory tract atrophy, and petechial hemorrhage, etc..From the 8th to 11th day of pregnancy.oral administration of PY forfour days continuously. The LDp and resorptive dosage of PY to therat embryos is 4.20 mgPY/Kg B. W. The dosage which can cause 50rat fetus became malformation is 2.18mgPY/Kg B. W. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。