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題名 | Pyrimethamine對雞胚胎致畸形性及其機轉之研究 |
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作者 | 郭宗甫; 劉朝鑫; | 書刊名 | 臺灣畜牧獸醫學會會報 |
卷期 | 64 1994.12[民83.12] |
頁次 | 頁47-56 |
分類號 | 437.21 |
關鍵詞 | 雞胚胎; 致畸形; 劑量; 機轉; Pyrimethamine; |
語文 | 中文(Chinese) |
中文摘要 | 雞胚給與0.5mg Pryimethaimine(PY)時,除了造成雞胚胎總死亡個數顯著增加外 ,對自然孵出雞胎數,活雞體重及雞胚胎畸形數目無顯著影響;給與雞胚胎1 mg PY(含) 以上時,將造成雞胚胎總死亡個數、孵出雞胎數及活雞體重分別有極顯著之增加、減少和下 降,且造成雞胚胎右腳趾關節僵直及上喙變形之畸形。孵育至第6、第7、第8及第9天之雞 胚胎,經由卵黃囊直接給與2 mg PY,繼續孵育經24小時後,雞胚胎二氫葉酸還原鋂(DHFR) 之活性及比活性皆受到極顯著之抑制作用。由PY直接對雞胚胎DHFR活性之抑制作用,其所 造成雞胚胎之死亡、及引起畸形之事實,證實PY致畸形性之作用機制乃是仰制DHFR活性, 影響核酸之合成,造成胚胎器官分化過程不協調所致。 |
英文摘要 | These studies used Shaver chicken embryos as experimental animals to achieve the following aims. 1) to 1explore the teratogenicity of PY to the chicken embryos; 2) to explore the direct effects of PY on the chicken embryos' differentiation and DHFR activity, by inoculated PY directly into yolk sac of chicken embryo; 3) to understand the teratogenesis of PY from the enzymological stand point. Given 0.5 mg PY to the chicken embryos, besides the significantly increasing of the natimortality of the chicken embryos, no any significant effect on natural hatched chicks' number, alive chicken body weight and number of chicken anormalies; given 1 mg/kg PY to the chicken embryos, the natimortality of chicken embryos, the hatched chick's number and alive chicken body weight are more significantly increased, decreased, and reduced respectively. Also, there are malformations of upper beak and stiff digital joint of chicken fetus. PY can directly inhibit the DHFR activity of chicken embryo. The fact that caused the dead of chicken embryo, and the teratogenicity, proved that the inhibition of DHFR activity and the interruption of nucleic acid synthesis, the mechanism of terato-genesis, can lead to abnormal embryonic organ differentiation. |
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