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題名 | Lack of Osmotic Control in the Release of Atrial Natriuretic Peptide in Cardiac Patients=心臟病患心房利鈉因子之釋放並未受到血漿滲透度之控制 |
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作者 | 朱凱民; | 書刊名 | 醫學研究 |
卷期 | 11: 附輯1 民80.04 |
頁次 | 頁67-77 |
分類號 | 398.31 |
關鍵詞 | 心房; 心臟病患; 血漿; 利鈉因子; 滲透度; |
語文 | 英文(English) |
中文摘要 | 20位心臟病人於接受心導管冠狀動脈攝影時,採用不同高滲透度顯影劑來探討局部滲透度改變對心房利納因子分泌的影響。心房利納因子於肺動脈血及主動脈血中顯著地較下腔靜脈血為高(分別為79.6±16.2pg/ml,87.1±18.1pg/ml及49.6±9.7pg/ml,平均值±標準誤,p值小於0.05)。在下腔靜脈血內的心房利納因子與右心房壓、肺動脈壓或心搏指數均無關聯。然而主動脈血中心房利納因子與心搏指數呈統計上有意義的負相關(r=-0.55,p<0.02)。而肺動脈血中心房利納因子與肺動脈壓呈正相關且與心搏指數呈負相關(r=0.57,p<0.01及r=-0.53,p<0.02)。冠狀動脈攝影所用的Telebrix(2000mosm/kg H₂O)或Hexabrix(600mosm/kg H₂O)並未造成血中心房利納因子明顯的改變。總結上述結果顯示,動脈血較靜脈血中的心房利納因子較能反映心臟的功能。短暫的冠狀動脈注射高滲透度顯影劑並未顯著地改變血中心房利納因子。 |
英文摘要 | The effect of osmotic change on the release of atrial natriuretic peptide (ANP) was evaluated in 20 patients during cardiac catheterization. ANP concentrations obtained in pulmonary artery (PA), and aorta (AO) were significantly higher than that inferior vena cava (IVC) (79.6±16.2 pg/ml, 87.1±18.1 pg/ml, and 49.6±9.7 pg/ml(mean ±SEM), respectively, p<0.05). ANP concentration in IVC did not correlate with the pressure in PA, right atrium, or with the cardiac index (CI). However, ANP concentration in AO was significantly correlated with CI (r=-0.55, p<0.02). ANP concentration in PA was also significantly correlated with mean PA pressure and CI (r=0.57, p<0.01 and r=-0.53, p<0.02, respectively). Injection of either of two contrast media (Telebrix, 2000 mosm/kg H₂O, or Hexabrix, 600 mosm/kg H₂O) into right coronary artery did not change ANP concentration. In conclusion, arterial instead of venous ANP might be a better predictor of cardiac function. Transient intracoronary injection of hypersmotic contrast media did not cause a significant change in the plasma ANP. |
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