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題名 | Plasma Levels of Atrial Natriuretic Factor in Normal Children and Patients Treated by Hemodialysis and Continuous Ambulatory Peritoneal Dialysis=正常兒童及末期腎病兒童於血液透析或連續可攜帶性腹膜透析治療前後之血漿心房利鈉尿因子濃度 |
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作者 | 楊令瑀; 陳偉鵬; 林清淵; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷期 | 34:1 民82.01-02 |
頁次 | 頁1-8 |
分類號 | 414.7 |
關鍵詞 | 心房; 末期; 因子; 血液透析; 血漿; 利鈉尿; 兒童; 治療; 腎病; 腹膜透析; 濃度; |
語文 | 英文(English) |
中文摘要 | 為了建立國人成長兒童之血漿心房利鈉尿因子(Atrial natriuretic factor, ANF)在各年齡層的正常參考值,及評估血液透析(Hemodialysis, HD)及連續可攜帶性腹膜透析(Continuous ambulatory peritoneal dialysis, CAPD)對血漿心房利鈉尿因子濃度的影響,吾人以50位腎功能正常的健康兒童及20位末期腎病(End-stage renal disease, ESRD)的病童為研究對象。20位病童中,有10位接受血液透析治療,15位接受連續可攜帶性腹膜透析治療。其中重覆的5位是先接受血液透析治療,之後再改為連續可攜帶性腹膜透析治療。結果顯示,在正常兒童中,血漿心房利鈉尿因子的濃度於出生後一個月內最高,而隨著年齡的增長,其濃度漸減。至於末期腎病兒童的血漿心房利鈉尿因子濃度在洗腎前明顯地比同年齡層的正常兒童高(434.1±80.1 Pg/ml及17.5±2.3 pg/ml, P<0.0001)。血液透析及連續可攜帶性腹膜透析均能降低血漿中的心房利鈉尿因子濃度,但其值仍然比正常值為高。而兩者在比較上,以連續可攜帶性腹膜透析更具有降低血漿心房利鈉尿因子濃度的作用(71.8±13.7pg/ml及270.3±51.9pg/ml, P<0.0001)。同時我們觀測到在血液透析前後,血漿心房利鈉尿因子的濃度變化與病童體重及血清肌氨酸酐值的變化有統計上的正相關。 |
英文摘要 | In an attempt to establish the reference data of plasma levels of atrial natriuretic factor (ANF) in different age groups and to evaluate plasma ANF changes before and after hemodialysis (HD) and during continuous ambulatory peritoneal dialysis (CAPD), fifty normal healthy children and 20 children with end-stage renal disease (ESRD) were included. Ten ESRD children received HD and 15 received CAPD therapy. Five cases received HD in the earlier period and then CAPD. The results showed that in normal children, at the age of under one month, there were higher plasma ANF levels. As age increased, plasma ANF levels progressively decreased. During the ESRD before dialysis, there was a significantly increased plasma ANF level (434.1±80.1 vs 17.5±2.3 pg/ml, P<0.0001). Both HD and CAPD reduced the plasma ANF of patients to a lower degree, but the result was still higher than that in normal controls. There were significantly decreased plasma ANF level in the patients with CAPD therapy than those with HD (71.8±13.7 vs 270.3±51.9 pg/ml, P<0.0001). The change of ANF levels was positively correlated with the body weight change and creatinine change after HD. |
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