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題 名 | Hormone Receptor in Breast Cancer and Its Relation to Recurrence and Survival=乳癌荷爾蒙接受體及其與腫瘤復發及存活之關係 |
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作 者 | 陳楷模; 張耀仁; 陳同仁; | 書刊名 | 中華民國外科醫學會雜誌 |
卷 期 | 24:1 民80.01-02 |
頁 次 | 頁513-520 |
分類號 | 416.226 |
關鍵詞 | 乳癌; 荷爾蒙接受體; 腫瘤復發; |
語 文 | 英文(English) |
中文摘要 | 動情素及助孕酮接受體(ER及PR)在乳癌病人的治療上漸趨重要。多數報告顯示ER及PR測定值已被用為乳癌病患對內分泌治療療效之指標。至於ER及PR測定是否可作為乳癌復發或存活的重要參數則仍有存疑。台大醫院於民國70年2月至77年2月間共測定307個乳癌手術患者的ER及PR值,於118個未停經患者27.13%為ER(+)PR(+),17.02%ER(+)PR(-),16.49%ER(-)PR(+),37.76%ER(-)PR(-),而113個停經患者中34.51%為ER(+)PR(+),20.35%ER(+)PR(-),7.08%ER(-)PR(+),38.05%ER(-)PR(-),雖然在腋下淋巴節轉移病人中,ER(+)PR(+)者的disease free survival及overal survival比ER(-)PR(-)者有較好的現象,但統計學上仍顯無意義。乳癌荷爾蒙接受體在預測腫瘤的復發及存活上,顯然比腋下淋巴節之有無轉移較為遜色。 |
英文摘要 | Estrogen and progesteron.e receptor (ER and PR) assays have become more important in the multimodal approaches for breast cancer patients not only their good indicators of endocrine therapy but also their possible prognostic role in recurrence and survival. The ER and PR values were measured in 307 breast cancer patients from Feb 1981 to Feb 1988. In 188 premenopausal patients, 27.13% were ER(+)PR(+), 17.02% ER(+)PR(-), 16.49% ER(-)PR(+) and 37.76% ER(-)PR(-). While in 113 postmenopausal patients, 34.51% were ER(+)PR(+), 20.35% ER(+)PR(-),7.08% ER(-)PR(+) and 38.05% ER(-)PR(-). The disease free survival and overal survival in the positive axillary lymph node (N+) group had the tendancy to have better results in ER(+)PR(+) patients than ER(-)PR(-),but the P value was not significant (P=0.5). The fact that the negative axillary lymph node (N-) group had obviously better disease free survival and overal survival as compared to the N+ group (P<0.05) showed the involvement of axillary lymph node had a more important prognostic role in the treatment of breast cancer. |
本系統中英文摘要資訊取自各篇刊載內容。