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題 名 | 支氣管氣喘患者的支氣管反應性以及抗壞血酸的影響 |
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作 者 | 徐剛; | 書刊名 | 醫學研究 |
卷 期 | 6:4 1986.06[民75.06] |
頁 次 | 頁311-316 |
分類號 | 415.425 |
關鍵詞 | 支氣管氣喘; 支氣管反應性; 抗壞血酸; |
語 文 | 中文(Chinese) |
中文摘要 | 抗壞血酸(維生素丙)和支氣管反應性之間的關係及臨床效果目前尚無統一意見。為了澄清這一問題,本文對20名典型支氣管氣喘患者(甲組)和33名非典型患者(乙組)用Methacholine激發試驗,觀察兩組患者在支氣管反應性上之差異以及口服維生素C(1.0g)對支氣管反應性的影響。反應性以使氣傳導性(specific airway conductance, SGaw)下降40%(簡稱PD[fee1])表示之。結果發現兩組患者在不發作期間,其支氣管反應性亦有明顯差異(P<0.01)。支氣管反應性增高的患者在氣喘不發作期間,其第一秒用力肺活量(FEV₁)、用力肺活量(FVC)、以及肺總量(TLC)等均可在正常範圍,但其氣道阻力(SRаw)增加,氣道傳導性下降,且與反應性增加之程度有關。上述兩組患者,其SRаw及SGаw平均值均超出正常預計值範圍,而兩者之間又有非常顯著之差異(P<0.01)。 兩組患者服用維生素丙後,PD[fee1]之變化均無統計學意義。甲組服用維生素丙後,有3名反應性提高,7名下降,10名無變動。PD[fee1]平均值由7.64±2.79單位,增至10.86±9.02單位,但無統計學之顯著性(P>0.05)。乙組則變化更小。用累積量和非累積量所得之結果,基本上是一致的。至於服用維生素丙後支氣管反應性增高、下降和無變化者之間,無論從年齡、性別、職業、過敏因素、基線肺功能情況等進行分析、結果均未見任合差異。總之,在本研究中維生素丙對支氣管氣喘患者的支氣管反應性無肯定性、明顯和規律性的降低作用。因此在臨床上利用維生素丙做為預防氣喘發作和治療的手段似嫌根據不足,尚須做更多深入之探討。 |
英文摘要 | Studies on the change of bronchial reactivity after ascorbic acid and clinical experience with this drug in asthma have yielded conflicting data. We studied the bronchial reactivity and the effect of ascorbic acid (Vitamine C) in 20 typical asthma patients (group A) and 33 atypical subjects (group B). The effect of ascorbid acid (1.0g orally) was assessed by the changes in concentration of methacholine required to decrease the specific airway conductance (SGаw) by 40% (PD[fee1]). According to our results, the bronchial reactivity of group A was significantly higher than that of group B (p<0.01). Baseline lung function tests showed that, FEV₁, FVC and TLC were all within normal limit in both groups, except specific airway resistance (SRаw) and SGаw. The increase of SR and decrease of SGаw were related to bronchial reactivity. There were significant differences of SRаw and SGаw between these two groups (p<0.01). There were no significant changes in PD[fee1] of both groups after ascorbic acid orally. In group A, 3 subjects increased in PD[fee1], 7 decreased, and ten remained no change. PD[fee1] increased, from control value of 7.46±2.79 units to 10.86±9.02 units, is not statistically significant (p>0.05). However, PD[fee1] changed even smaller in group B. The results calculated by cumulative or non-cumulative units were about the same. We therefore concluded that the effect of ascorbic acid on bronchial reactivity in asthmatic subjects was uncertain. Ascorbic acid might be of little benefit in the prevention or treatment of asthma. Further detailed investigations in this field are certainly necessary. |
本系統中英文摘要資訊取自各篇刊載內容。