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頁籤選單縮合
| 題 名 | Autoantibodies Associated with Renal Involvement in Patients with Systemic Lupus Erythematosus=紅斑性狼瘡病人腎臟侵犯與否與自體抗體間之相關性 |
|---|---|
| 作 者 | 桂秀平; 施勇綸; 李進成; 莊志誠; | 書刊名 | Journal of Biomedical & Laboratory Sciences |
| 卷 期 | 18:1-4 2006[民95] |
| 頁 次 | 頁23-28 |
| 分類號 | 415.6951 |
| 關鍵詞 | 自體抗體; 腎臟侵犯; 紅斑性狼瘡; Autoantibody; Renal involvement; Systemic lupus erythematosus; SLE; |
| 語 文 | 英文(English) |
| 中文摘要 | 狼瘡腎炎通常與抗雙股去氧核醣核苷酸抗體有關。此篇研究的目的,即在於探討國人紅斑性狼瘡 病例中,這些自體抗體與腎臟侵犯的相關性。我們回溯性研究了1999年到2002年間,於本院過敏 免疫風濕科接受治療的57位紅斑性狼瘡病人的病歷資料。根據持續性蛋白尿出現與否來判定紅斑 性狼瘡病人是否有腎臟侵犯,以回溯性呈現診斷時的抗體。具腎臟侵犯的紅斑性狼瘡病人占35%, 有腎臟侵犯的病人比沒有腎臟侵犯的病人較常出現抗Ro抗體(16/20比19/37,p=0.034)或抗牛心 脂素抗體(15/20比13/37,p=0.004)。另外,有腎臟侵犯的病人具有較低的補體(C3)值占65%。 腎臟侵犯與否和抗雙股去氧核醣核 酸、抗 苷 La抗體、抗Sm抗體及抗nRNP抗體較無相關,腎臟侵 犯的紅斑性狼瘡病人與抗Ro抗體或抗牛心脂素抗體具有意義的相關。 |
| 英文摘要 | Lupus nephritis has often been associated with anti-ds DNA. The aim of this study was to investigate whether renal involvement of systemic lupus erythematosus (SLE) was associated with any autoantibody patterns. Medical records of patients with SLE (57 patients) seen from 1999 through 2002 by the rheumatology service at the Shin Kong Wu Ho-Su Memorial Hospital were retrospectively analyzed. Persistent proteinuria was used as the evidence of renal involvement among the SLE patients. Results of autoantibody tests at diagnosis were identified retrospectively. Twenty (35%) of the 57 SLE patients had renal involvement. Anti-Ro/SS-A antibodies were present in the serum of 16 of the 20 (80%) patients with renal involvement and 19 of the 37 (51%) without renal involvement (p=0.034). IgG anti-cardiolipin antibodies (IgG aCL) were present in the serum of 15 of the 20 (75%) patients with renal involvement and 13 of the 37 (35%) without renal involvement (p=0.004). In addition, low levels of complement C3 were present in the serum of 13 of the 20 (65%) patients with renal involvement. Anti-ds DNA, anti-La/SS-B, anti-Sm, and anti-nRNP antibodies showed no correlation with renal involvement. Renal involvement in our SLE population was frequently found and the results correlated significantly with the presence of anti-Ro/SS-A, IgG aCL autoantibodies. |
本系統中英文摘要資訊取自各篇刊載內容。