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| 題 名 | 桂枝複方抗炎功效研究=Study on the Anti-Inflammatory Effect of Guizhi Compound |
|---|---|
| 作 者 | 林文宏; 陳亮均; | 書刊名 | 大數據應用與管理 |
| 卷 期 | 5 2025.07[民114.07] |
| 頁 次 | 頁9-15 |
| 分類號 | 415.237 |
| 關鍵詞 | 桂枝複方; 流感; 發炎因子; 巨噬細胞; Guizhi compound; Influenza; Inflammatory factors; Macrophage; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 流感(Influenza)引起的疾病一直是人類常見 的問題。臺灣正處於亞熱帶地區,流行期不僅僅只 侷限於冬天,而是全年皆有流行的機會,因此進行 材料抗炎活性分析。本研究選採桂枝複方為素材, 進行抗發炎活性分析,觀察是否具備抗炎緩解流感 症狀為本研究之目的。進行細胞層面分析,以≦160 微米粒徑,區分二組為有造粒組與無造粒組,依不 同濃度分別作用於巨噬細胞株(RAW 264.7),包 括一氧化氮(NO)、白介素 6(IL-6)及腫瘤壞死 因 子 -α ( TNF-α ) 等 發 炎 激 素 。 研 究 結 果 顯 示 在 5.0% 、7.5%及 10.0 % 測試濃度下,不論有或無造 粒,均具顯著抑制 NO 產生的效果,其餘則無抑制反 應。本研究結論表明,桂枝複方≦160 微米粒徑,可 降解抗炎效力,在抑制 NO 產生量,具顯著表達抑制 效果;同時,無造粒組抑制率優於有造粒組抗炎效 力,說明造粒製程中使用的賦形劑(excipient ), 可能降解抗炎效力;但在 IL-6 與 TNF-α 生成之抗炎 效果,則無抗炎效力。以此結論,提供產業提升效 益應用發展參考。 |
| 英文摘要 | The disease caused by influenza has always been a common problem in humans. Taiwan is in the subtropical region, and the epidemic period is not limited to winter, but also has the opportunity to be epidemic throughout the year, so the anti-inflammatory activity of the material was analyzed. The purpose of this study was to use Guizhi compound as the material to detect and analyze the anti-inflammatory activity, and to observe whether it has anti-inflammatory and alleviating influenza symptoms. Cell-level analysis was carried out, and the two groups were divided into granulation group and non- granulation group with a particle size of ≦160 microns, and acted on macrophage cell lines (RAW 264.7) according to different concentrations, including inflammatory hormones such as nitric oxide (NO), interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α). The results showed that at the test concentrations of 5.0%, 7.5% and 10.0%, both with and without granulation, there was a significant inhibitory effect on NO production, while the rest had no inhibitory effect. The conclusion of this study showed that the ≦ 160 micron particle size of Guizhi compound had degradable and anti-inflammatory effects, and had a significant expression inhibitory effect in inhibiting the production of NO. At the same time, the inhibition rate of the non- granulation group was better than that of the granulation group, indicating that the excipient used in the granulation process may degrade the anti-inflammatory efficacy. However, there is no anti-inflammatory effect in the anti-inflammatory effect of IL-6 and TNF-α. This conclusion can increase efficiency for industrial development and provide reference for application development. |
本系統中英文摘要資訊取自各篇刊載內容。