頁籤選單縮合
題 名 | Prevalence of Antipsychotic Drugs Related to Constipation in Patients with Schizophrenia=服用抗精神病藥物治療之思覺失調症病人的便秘盛行率調查 |
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作 者 | 呂宇席; 陳玉真; 郭詩憲; 蔡景宏; | 書刊名 | Taiwanese Journal of Psychiatry |
卷 期 | 30:4 2016.12[民105.12] |
頁 次 | 頁294-299+a9 |
分類號 | 418.21 |
關鍵詞 | 便秘; 思覺失調症; 抗精神病藥物; 盛行率; Constipation; Schizophrenia; Antipsychotics; Prevalence; |
語 文 | 英文(English) |
英文摘要 | Objective: Constipation is thought to be both common and overlooked in patients with schizophrenia, with no empirical data about its prevalence in the schizophrenic population in Taiwan. In the current study, we intended to investigate prevalence and risk factors of constipation during routine treatment of patients with schizophrenia. Method: We did a retrospective study of inpatients treated with antipsychotic medications in Kaohsiung Kai Syuan Municipal Psychiatric Hospital between January 2008 and December 2013. Totally, 3,107 inpatients diagnosed as schizophrenic were included in this study. Results: The prevalence of constipation was 28.10%. Female gender (odds ratio = 2.12, 95% confidence interval = 1.76 - 2.55, p < 0.01), older age (OR = 1.02, 95% CI = 1.76 - 2.55, p < 0.01), greater symptom severity (OR = 1.03, 95% CI = 1.01 - 1.04, p < 0.01), and comorbid medical diseases (OR = 1.99, 95% CI = 1.65 - 2.40, p < 0.01) were found to be all significantly positive factors related to the constipation. We also found that the use of second-generation antipsychotic drugs (OR = 1.75, 95% CI =1.24- 2.48, p < 0.01), and the use of SGAs combined with first-generation antipsychotic drugs (OR = 3.78, 95% CI = 2.70 - 5.28, p < 0.01) were significantly more likely to cause constipation than the use of FGAs alone. Conclusion: Those findings suggest that clinicians need greater vigilance and active evaluation of constipation in patients with schizophrenia, to ensure appropriate clinical management and to prevent associated complications. |
本系統中英文摘要資訊取自各篇刊載內容。