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頁籤選單縮合
題 名 | 化療藥物引起的皮膚毒性=Chemotherapeutic Agents Associated Skin Toxicities |
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作 者 | 蔡佩芬; 許育瑋; | 書刊名 | 藥學雜誌 |
卷 期 | 32:2=127 2016.06[民105.06] |
頁 次 | 頁63-68 |
分類號 | 418.33 |
關鍵詞 | 化學治療; 化療藥物; 細胞毒性藥物; 皮膚毒性; |
語 文 | 中文(Chinese) |
中文摘要 | 過去數十年間隨著化療藥物的發展,癌症患者在存活率上獲得明顯改善,但也因為 化療藥物的廣泛使用,相關毒性的發生機會也隨之增加。傳統細胞毒性藥物藉由干擾 DNA 的複製而發揮抗腫瘤的效果,除了作用在癌細胞外,也會影響像是頭髮、指甲、 皮膚及黏膜等快速分裂的細胞,造成相關的皮膚毒性,導致藥物劑量可能必須降低,治 療必須中斷甚至停止的情況。 多數的傳統細胞毒性藥物已知會出現如掉髮、口腔黏膜炎、乾燥症、指甲改變、過 敏及外滲等非專一性的皮膚反應;另外也可能出現如放射線回憶反應、毒性紅斑、色素 沉著及肢端紅腫症等的專一性皮膚症狀。口腔冷卻法是目前避免口腔黏膜炎較明確的預 防措施,但對於細胞毒性藥物其他的皮膚毒性,除了降低劑量或停用問題藥物外,並無 明確的治療與預防方式。 化療藥物引起的皮膚毒性並不罕見,但發生的初期往往容易被忽略,醫療人員對這 些化療藥物的皮膚毒性應有一定的認識與了解,必要時才能提供適當的介入以降低皮膚 毒性的嚴重度。 |
英文摘要 | Over the past few decades, the survival and the incidence of toxicities in cancer patients were increased by the development of chemotherapeutic agents. Conventional cytotoxic agents exert antitumor activities by interfering the process of DNA replication, affecting tumor cells as well as rapidly dividing cells including the hair, nails, skin, and mucosa, which may lead to dose reduction, interruption or discontinuation of cancer therapy. Cytotoxic agents may cause nonspecific skin complications such as alopecia, mucositis, nail change, hypersensitivity and extravasation reactions. Furthermore, radiation recall, acral erythema, hyperpigmentation and toxic erythema are specific skin complications which have been seen. Although oral cryotherapy was found to be effective in mucositis prevention, however, there has no effective measures in prevent and management other skin toxicities caused by cytotoxic agents, except dose reduction or cessation of the causative agent. Skin toxicity occurs frequently with chemotherapeutic agents. Early recognition and management of these toxicitys may play an important role in provide optimal care for cancer patients. |
本系統中英文摘要資訊取自各篇刊載內容。