查詢結果分析
相關文獻
- Heme Oxygenase-1 Is Involved in the Protective Effect of 17-DMAG in Heat Stroke Rats
- 延胡索成分四氫巴馬汀對熱中風動物模式之療效評估
- 厚朴酚對熱中風動物模式療效之評估
- Mesenchymal Stem Cells Derived from Human Umbilical Cord Attenuate the Mortality Rate of Experimentally Induced Heatstroke
- Effects of Administration with BQ 788 on Heat Stroke in Rats
- Effects of Intermittent Hypoxia Adaptation on Experimental Heatstroke Rat Model
- Heme Oxygenase-1 in Cardiovascular Diseases: Molecular Mechanisms and Clinical Perspectives
- Hypothermic Retrograde Jugular Vein Flush with Saline and Perfluorocarbons in Heatstroke of Rats
- 非毒性劑量下肉桂醛提高第一型血基質氧化酶基因表現
頁籤選單縮合
題 名 | Heme Oxygenase-1 Is Involved in the Protective Effect of 17-DMAG in Heat Stroke Rats=探討保護性HO-1在給予17-DMAG治療熱中風鼠的角色 |
---|---|
作 者 | 孔慶聞; 王奕力; 李燕媚; | 書刊名 | 慈濟科技大學學報 |
卷 期 | 2=26 2016.03[民105.03] |
頁 次 | 頁35-48 |
分類號 | 415.922 |
關鍵詞 | 熱中風; 熱休克蛋白90抑制劑; 第一型血基質氧化酶; Heat stroke; Heat shock protein 90 inhibitor; 17-DMAG; HO-1; |
語 文 | 英文(English) |
中文摘要 | 熱中風 (Heat stroke; HS) 是一種具生命威脅性的疾病,其特點為中心體溫上升超過40℃,且伴隨有譫妄、癲癇或昏迷等中樞系統異常之症狀。儘管積極的使其體溫下降並給予支持性治療,熱中風仍具有極高死亡率。因此,本實驗目的在以雄性Sprague-Dawley (SD)大白鼠誘發熱中風模式時,未給予或預先給予熱休克90抑制劑17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) 來評估熱休克發生期間17-DMAG是否能保護肝臟免於功能不良。將重280-350公克雄性SD大白鼠以urethane (1.4 g/kg)進行腹腔注射麻醉後,利用聚乙烯管在動物右側股動脈及股靜脈插管。動物分為兩組:(1)溶劑(normal saline) +熱中風(HS)組:熱中風生成判斷以平均動脈壓迅速下降25 mmHg及大鼠肛溫大於42℃視為熱中風生成;(2) 17-DMAG + HS組:於熱中風前20小時腹腔注射17-DMAG (5 mg/kg)。熱中風時實驗測量兩組動物的:(1)平均動脈壓及心跳;(2)血清肝功能生化參數;(3)肝臟中第一型血基質氧化酶 (Heme oxygenase-1, HO-1)的表現量。實驗結果顯示:熱休克(HS)組之平均動脈壓及心跳比17-DMAG + HS組來得低,預先處理17-DMAG能有效改善平均動脈壓及心跳;預先給17-DMAG(17-DMAG + HS)組肝臟中之HO-1表現明顯比熱休克組(HS)高。研究結果證明17-DMAG可以改善熱休克鼠血液動力學及肝功能,此可能與增加HO-1表現有關。 |
英文摘要 | Heat stroke is a life-threatening illness characterized by an elevated core body temperature that rises above 40℃ and central nervous system dysfunction that results in delirium, convulsions, or coma. Despite adequate lowering of the body temperature and aggressive support treatment, the mortality of heat stroke is still high. Thus, the aim of the present study is to evaluate whether 17-dimethylaminoethylamino-17- demethoxygeldanamycin (17-DMAG), a heat shock protein (HSP) 90 inhibitor, improves hemodynamic changes, and hepatic dysfunctions in heat stroke. Male Sprague-Dawley rats (280-350 g) exposed to heat as a model of heat stroke. The right femoral artery and vein of rats, under urethane (1.4 g/kg, ip) anesthesia, were cannulated with polyethylene tubing (PE 50). Two groups of animals were studied; (1) Vehicle-treated heat stroke group (HS group): heat stroke was induced by putting the rats into a chamber at 42℃. It is characterized when mean arterial blood pressure (MAP) dropped to a value of 25 mmHg from the peak level and Tco (core body temperature) elevated to about 42℃; (2) 17-DMAG + HS group: rats were pretreated with 17-DMAG (5 mg/kg, ip) 20 h before heat stroke. The values of MAP and heart rate of rats in HS group were significantly lower than those of 17-DMAG + HS group. 17-DMAG significantly prevented hypotension, and elevated plasma level of GPT induced by heat stroke. The expression of HO-1 in liver of 17-DMAG + HS group was significantly higher than that of HS group. In conclusion, 17-DMAG improves hemodynamics and hepatic function of heat stroke rats, which may be mediated by the increase of HO-1 induction. |
本系統中英文摘要資訊取自各篇刊載內容。