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| 題 名 | Heme Oxygenase-1 in Cardiovascular Diseases: Molecular Mechanisms and Clinical Perspectives=第一型血基質氧化酶與心血管疾病:分子作用機制與臨床之重要性 |
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| 作 者 | 王朝永; 趙麗洋; | 書刊名 | 長庚醫誌 |
| 卷 期 | 33:1 2010.01-02[民99.01-02] |
| 頁 次 | 頁13-24 |
| 分類號 | 415.13 |
| 關鍵詞 | 第一型血基質氧化酶; 一氧化碳; 膽黃素; 心血管疾病; Heme oxygenase-1; Carbon monoxide; Bilirubin; Clinical perspectives; |
| 語 文 | 英文(English) |
| 英文摘要 | Heme oxygenase (HO) catalyzes the rate-limiting step in the oxidative degradation of cellular heme that liberates iron, carbon monoxide (CO), and biliverdin. Two distinct HO isoforms have been identified in mammalian system. Compared to HO-2, which is constitutively expressed, HO-1 is a stress-responsive protein that is highly induced by many agents, including cytokines, endotoxin, heavy metals, nitric oxide and its own substrate heme. In addition to its well-defined role in heme catabolism and erythrocyte turnover, HO-1 also plays an important function in various physiological and pathophysiological states associated with cellular stress. Over the past decade, compelling evidence has revealed that the induction of HO-1 represents an important defensive mechanism against further oxidative injury in tissues and cells following various insults; this occurs by virtue of the anti-inflammatory and antioxidant capacities of CO, biliverdin, and the subsequent metabolite of biliverdin, bilirubin. In line with the findings from the basic research, numerous studies have supported the importance of HO-1 in various clinical diseases, including coronary artery disease, cardiac hypertrophy, diabetes mellitus, ischemic/reperfusion injury, atherosclerosis and cancer. This review provides an overview on the regulation and function of HO-1, ranging from the molecular mechanisms involved to various clinical perspectives. Specifically, there is a focus on the enzyme’s role in various cardiovascular diseases. |
本系統中英文摘要資訊取自各篇刊載內容。