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題名 | 以改良式浸沾塗佈法將電氣紡絲混合生物活性分子製成PCL奈米纖維支架之研究=Coating Electrospun PCL Scaffold with Biologically Active Molecules by the Improved Dip-coating |
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作者 | 何宜倩; 陳彥宇; 李淑芬; 王鐘毅; | 書刊名 | 耕莘學報 |
卷期 | 12 2014.12[民103.12] |
頁次 | 頁60-66 |
分類號 | 478.1 |
關鍵詞 | 電氣紡絲; 聚己內酯; 膠原蛋白; 浸沾式塗佈法; Electrospinning; PCL; Poly(ε-caprolactone); Collagen; Dip-coating method; |
語文 | 中文(Chinese) |
中文摘要 | 關節的損傷和退化性關節炎為重要的研究課題,器官移植或植入適當替代材料便成為常見的治療方式。近年來普遍以電氣紡絲技術製備組織工程支架材料,許多研究亦採用不同的生物活性分子來修改其生物相容性。浸沾式塗佈法為早期使用的表面修改方法,此方法之優點為快速、無毒且不會破壞材料本身的性質,但電氣紡絲支架具有孔徑小,容易被塗層溶液覆蓋之缺點,故本研究中以改良式浸塗法來解決此問題,討論其表面結構,孔隙率,膠原含量和生物相容性。結果發現以氮氣處理90°、1分鐘能夠將其孔隙度提高,同時維持一定的膠原蛋白含量,並增加生物相容性,可見使用膠原浸塗法可製成一種潛在的軟骨組織工程支架。 |
英文摘要 | Joint damage and degenerative arthritis has become an important research topic. Organ transplant or implant suitable alternative materials have become a common treatment. Fabrication tissue engineering scaffold by electrospinning was in common use in these years, and many reports using different bioactive molecular to modify their biocompatibility. Dip-coating was an ancient surface modifies method, which had several advantages such as fast, non-toxic, and will not influence the characterization of material. But electrospun scaffold had small pore size, easily covered by coating solution. In this study, centrifugal treatment was employed to solve this problem, and discussed their surface morphology, porosity, collagen content and biocompatibility. The results showed that porosity can be increased while maintaining a certain degree of collagen content, and increased biocompatibility by treatment with nitrogen gas with 90 for 1 minutes. This proved that using collagen dip-coating method and after-coating centrifugal treatment could fabricated a potentially cartilage tissue engineering scaffolds. |
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