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題名 | 利用代謝體學建立龍膽中藥材生產品質管制種植規範(GAP)=Establishment of GAP on Gentiana Scabra Using Metabolomic Strategy |
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編 次 | (2-2) |
作者 | 張文德; | 書刊名 | 中醫藥年報 |
卷期 | 3 2014.12[民103.12] |
頁次 | 頁(70)1-(70)58 |
分類號 | 413.97 |
關鍵詞 | 龍膽; 保肝作用; 中藥材生產品質管制種植規範; GAP; Gentiana scabra; Hepatoprotective effect; Good agriculture practice; |
語文 | 中文(Chinese) |
中文摘要 | GAP(Good Agriculture Practice)為國際要求的優良種植規範,主要分三個體系:藥材質量體系、操作規範及後期加工標準。從育種土壤開始,到施肥、農藥、栽培、採集等各個環節都需要有標準規範。中藥材龍膽原植物為粗糙龍膽(Gentiana scabra Bunge),具有保肝利膽、清熱瀉火之功效。現代科學化的藥理研究亦證明具有保肝、利膽、健胃、抗發炎、抗過敏及骨骼肌鬆弛等作用。台糖公司研究所已成功地利用組織培養技術自龍膽出瓶苗株中選拔耐熱個體株,於控制環境下建立龍膽組織培養母瓶並進行增殖,降低產程中微生物污染之損耗,提高組織培養苗生產效率。並在溫室種植試驗,對栽培期間之病蟲害及環境因素進行病原性測定及防治管理,提供龍膽產業化生產收穫規範之依據。 本計畫針對台糖公司研究所所生產之龍膽藥材,與中國生產之龍膽藥材,進行藥理活性之分析研究,探討台灣生產之龍膽藥材取代中國進口龍膽藥材的可能性,結果發現在肝臟損傷的保護評估,除了台灣種植的龍膽根部比大陸進口之藥材有相當不錯的效果外,由台糖自行開發之組織培養苗,對小鼠的急性肝炎預防有更大的效果,其結果甚至比正對照組的 Silymarin的療效還好。其作用機轉之一可能藉由防止 SOD、GPx和 GRd等抗氧化酵素活性下降,因而減少肝臟組織中 MDA及 NO的生成量,增加體內抗氧化能力,降低四氯化碳代謝過程中所產生之過氧化物或活性自由基所造成之肝臟損傷。 |
英文摘要 | There are three main aspects involved into the international guideline of Good Agriculture Practice (GAP), including materials quality, manipulation guides and processing standard. Each step has to be set up the standard guideline from breeding, propagation, cultivation management and diseases control. Gentiana scabra is the original plant for Chinese medicinal Long Dan (Radix Gentianae) which acts on the liver and gallbladder channels. It has the functions of quenching fire of liver and gallbladder and eliminating damp-heat. The effects in pharmacology are stomachic, hepatoprotective and choleretic, hypotensive and diuretic, as well as antibacterial and anti-inflammatory. Taiwan Sugar Research Institute has successfully screened the heat-resistant plant from mericlones of G. scabra using tissue cultures and propagated under controlled systems to enhance the efficiency of mericlones production. Then, the detection and prevention arrangements were conducted for blight and environmental factors during the cultivation in the greenhouse. These findings are able to be a basis for production and harvest of G. scabra in industrial scale. The main aim of this project is to evaluate the pharmacological activities of materials of G. scabra produced by Taiwan Sugar Research Institute and materials from China, such as stomach empting test, and hepatitis test. The hepatoprotective effect of G. scabra was evaluated based on carbon tetrachloride (CCl4)-induced liver injury. The results showed significant inhibition of the increase of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). G. scabra decreased the malondialdehyde (MDA) level and elevated the content of reduced glutathione (GSH) in the liver as compared to those in the CCl4 group. Furthermore, G. scabra enhanced the activities of anti-oxidative enzymes including superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRd) and glutathione-S-transferase (GST). The hepatoprotective mechanisms of G. scabra were likely associated to the decrease in MDA level and increase in GSH level by increasing the activities of antioxidant enzymes such as SOD, GPx, GR and GST. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。