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題名 | 抗癲癇藥與嚴重皮膚過敏反應=Antiepileptic Drugs Related Severe Cutaneous Adverse Reactions |
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作者 | 顏靜卉; 陳宛君; 林梅芳; 王彥棠; | 書刊名 | 藥學雜誌 |
卷期 | 31:1=122 2015.03[民104.03] |
頁次 | 頁59-64 |
分類號 | 418.21 |
關鍵詞 | 嚴重皮膚過敏反應; 抗癲癇藥; 毒性表皮溶解症; 史帝文生-強生症候群; HLA-B*1502; |
語文 | 中文(Chinese) |
中文摘要 | 嚴重皮膚過敏反應,如史帝文生-強生症候群 (Stevens-Johnson syndrome, SJS), 毒性表皮溶解症 (toxic epidermal necrolysis, TEN) 及藥物疹合併嗜伊紅血症及全身症 狀 (drug reaction with eosinophilia and systemic symptoms, DRESS),皆屬於延遲反應型 藥物過敏反應,常發生在不同的藥物中,其中包括一些常用的抗癲癇藥;抗癲癇藥引 致的嚴重皮膚過敏反應致死率為6.49%。在台灣,芳香族抗癲癇藥是導致 SJS 及 TEN 的主因,並且為產生 DRESS 的次要原因。而抗癲癇藥中 carbamazepine 被報導為台灣 最常引起 SJS/TEN 的藥物,而 phenytoin 則常導致 DRESS。因此,病人及臨床工作者 除了瞭解治療前所需完成的檢查外,更須衛教病人注意相關症狀及密切監測用藥後的 相關副作用,以適時的給予治療避免重大不良反應發生。 |
英文摘要 | Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrosis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS) are delayed-type drug hypersensitivity reactions. They occured in associated with different medications, including some commonly used antiepileptic drugs (AEDs). The mortality rate of AED-SCARs were 6.49%. In Taiwan, it seems that aromatic AEDs is the main cause for SJS and TEN, and is a secondary reason for DRESS occurred. Among those AEDs, carbamazepine is the most common drug to cause SJS/TEN, and DERSS usually caused by phenytoin. In order to provide proper medical care and avoid severe adverse drug reactions, the patients should not only know to carry out some laboratory test before taking these agents, but also need to know these ADEs related symptoms and close monitor these drugs related side effects after taking these anti-epileptic agents. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。