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題 名 | 史蒂芬-強森症候群和毒性表皮性壞死鬆解症--病例報告與文獻回顧=Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis--A Case Report and Review of the Literatures |
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作 者 | 陳意方; 朱正偉; 汪經堯; 劉敏英; | 書刊名 | 國防醫學 |
卷 期 | 31:6 2000.12[民89.12] |
頁 次 | 頁732-737 |
分類號 | 418.21 |
關鍵詞 | 抗癲癇藥物; 史蒂芬-強森症侯群; 毒性表皮性壞死鬆解症; Anti-epileptic drugs; Stevens-Johnson syndrome; SJS; toxic epidermal necrolysis; |
語 文 | 中文(Chinese) |
中文摘要 | 本篇病例報告提出一位尿毒症及冠狀動脈心臟病患者,接受了冠狀動脈繞道手術後,卻不幸在術後發生了急性胰臟炎、動靜脈廔管感染以及癲癇。在接受鄉抗癲癇藥物dilantin治療後,又引起了全身性皮疹和水泡脫屑變化。臨床診斷為史蒂芬-強森症候群(Steven-Johnson syndrome,簡稱"SJS"),並且進展到毒性表皮性懷死鬆解症(toxic epidermal necrolysis,簡稱"TEN")。病人在本院加護中心積極治療後仍不治死亡。預防嚴重的藥物性皮膚反應是相當困難的,這個病例提醒臨床醫師當病患接受藥物治療時,須注意是否有皮慮反應。一旦懷疑有藥物性皮膚反應,一些可能的藥物需立即停用,以防止皮膚病灶繼續擴大。 |
英文摘要 | We reported one patient who had uremia and coronary artery disease and received coronary artery bypass surgery. Acute pancreatitis, arterio-venous fistula infection and seizure developed after operation. The widespread skin eruption with bullous formation and desquamation occurred after anti-epileptic treatment with "dilantin". He wad diagnosed as SJS and then progressed into TEN. He expired at intensive care unit of our hospital in spite of aggressive managements. Prevention of severe drug-induced skin reactions is difficult. This case reminds the clinical physician that patients who receive any medication should be regularly monitored for cutaneous manifestation. If drug-induced skin reaction is suspected, the possible drugs must be discontinued promptly to avoid the progression of skin diseases. |
本系統中英文摘要資訊取自各篇刊載內容。