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題名 | 高張食鹽水用於小兒急性細支氣管炎=Efficacy of Nebulized Hypertonic Saline on Children with Acute Bronchiolitis |
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作 者 | 郭小懷; 胡雅姿; 林小絹; 管珮如; 李松澤; | 書刊名 | 藥學雜誌 |
卷期 | 31:1=122 2015.03[民104.03] |
頁次 | 頁6-10 |
分類號 | 415.426 |
關鍵詞 | 急性細支氣管炎; 3%高張食鹽水; 0.9%生理食鹽水; 幼兒; Acute bronchiolitis; |
語文 | 中文(Chinese) |
中文摘要 | 急性細支氣管炎是一常見的下呼吸道感染,好發於兩歲以內的嬰幼兒,近來有研 究指出高濃度生理食鹽水可用於治療急性細支氣管炎,本研究探討3%高張食鹽水與 0.9%生理食鹽水用於治療兩歲以下急性細支氣管炎住院病童之成效,包括住院天數及 臨床症狀的改善。收案期間為102年11月1日至103年3月31日,總收案人數為42人,實 驗組 (3%高張食鹽水) 共18人,對照組 (0.9%生理食鹽水) 共24人。在平均住院天數方 面,實驗組是5.61天,對照組是6.21天;以平均臨床嚴重度分數來看,實驗組和對照 組在第二及第三天的平均臨床嚴重度分數有統計學上顯著的差異 (day 2, p = 0.024; day 3, p = 0.044) 。目前高張食鹽水的治療角色仍未有定論,希望未來可納入更多樣本數 及進一步確認不同濃度高張食鹽水於急性細支氣管炎的療效。 |
英文摘要 | Acute bronchiolitis is common in children under the age of two. Recent studies indicated some benefits of hypertonic saline for treating acute bronchiolitis. The aim of this study is to investigate whether inhaled hypertonic saline for children under the age of two with acute bronchiolitis can reduce the length of hospital stays and clinical severity score compared to normal saline from September 2013 to March 2014. We included 42 patients. 18 patients were assigned to hypertonic saline group and 24 patients were assigned to normal saline group. The average hospital stay was 5.61 days in hypertonic saline group and 6.21 days in normal saline group. The clinical severity scores were significantly different between the two groups on day 2 and day 3 (day 2, p = 0.024; day 3, p = 0.044). The effect of hypertonic saline for treating acute bronchiolitis is controversial. Further studies and larger sample size are required to confirm the efficacy of using hypertonic saline instead of normal saline for treating acute bronchiolitis. |
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