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題 名 | 侵襲性乳癌之預後因子=The Prognostic Factors for Invasive Breast Cancer |
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作 者 | 林哲斌; 周碧瑟; 璩大成; | 書刊名 | 北市醫學雜誌 |
卷 期 | 10:2 2013.06[民102.06] |
頁 次 | 頁10-19 |
分類號 | 416.226 |
關鍵詞 | 乳癌; 預後因子; Breast cancer; Prognostic factors; C.I.; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究旨在探討單一醫療機構,採用標準的治療指引下,不同的預後因子對乳癌患者治療預後之影響。方法:我們檢視2004至2009在臺北市立聯合醫院仁愛院區不同分期經治療之502位女性侵襲性乳癌患者,分析各項預後因子對疾病存活及復發之影響。結果:在單變項之存活分析中發現,生物標記因子方面,動情激素受體陰性,黃體激素受體陰性,AJCC分期較晚,及腋下淋巴結轉移陽性,有相對較高的死亡風險。社經狀況方面則呈現,年齡>55歲,無伴侶者,使用自費藥物,教育程度大專以下,有較高之死亡風險。人體測量學方面,BMI並未呈現影響存活的任何意義,不過在多變項存活分析中則發現AJCC分期,動情激素受體與教育程度可呈現獨立之存活預後指標。結論:疾病的預後因子,在不同的時代、不同的治療下,重要程度可能不太相同。預後因子的再檢視有其臨床意義與重要性。 |
英文摘要 | The prognostic factors (PF) that influence the survival of breast cancer (BCA) patients, can be classified as (1) Clinical and biological factors: staging, axillary lymph nodes (LN), estrogen receptors (ER), progestrone receptors (PR), Her-2 receptors. (2) Social economic factors: Age, education, spouse, occupation, pocket-money medication. (3) Anthropometric factor: body mass index (BMI). We tried to figure out the influence of these PF in a single institute with standard treatment of breast cancer. Methods: We included 502 invasive BCA patients in Taipei City Hospital, Ren-Ai Branch, from 2004 to 2009. The survival data was analyzed by Cox Regression Method. Results: In univariate survival analyses, patients with characteristics of "age more than 55", "low education level", "pocket money medication", "advanced stage", "ER(-)", "PR(-)", "more than 3 axillary's LN" appeared significantly higher hazard ration (HR). However, by multivariate analyses after adjusting for all known PF, and Exclude the Lymph node status, we found AJCC staging, estrogen status, and education, can independently predict the prognosis. Conclusion: The prognosis of a disease may changes as the treatment improved. Re-evaluate the PF in different era is necessary. |
本系統中英文摘要資訊取自各篇刊載內容。