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| 題 名 | Adhesion Family of G Protein-coupled Receptors and Cancer=附著性G蛋白偶聯受體與癌症 |
|---|---|
| 作 者 | 林錫賢; | 書刊名 | 長庚醫誌 |
| 卷 期 | 35:1 2012.01-02[民101.01-02] |
| 頁 次 | 頁15-27 |
| 分類號 | 415.138 |
| 關鍵詞 | G蛋白偶聯受體; 血管新生; 細胞遷移; 細胞侵犯能力; 癌細胞轉移; 腫瘤生成; Adhesion-GPCR; Angiogenesis; Migration; Invasion; Metastasis; Tumorigenesis; |
| 語 文 | 英文(English) |
| 英文摘要 | The adhesion-class G protein-coupled receptors (adhesion-GPCRs) constitute the second largest GPCR sub-family in humans. Adhesion-GPCRs are defined by the chimeric structure of an unusually large extracellular cell-adhesion domain and a GPCR-like seven-pass transmembrane domain. Adhesion-GPCRs are hence expected to display both cellular adhesion and signaling functions in many biological systems. Adhesion-GPCRs are normally expressed in the central nervous, immune, and reproductive systems in a cell type- or tissue-restricted fashion. However, aberrant expression of distinct adhesion-GPCR molecules has been identified in various human cancers with some of the receptors closely associated with cancer development. Tumor-associated adhesion-GPCRs are thought to involve in tumorigenesis by affecting the growth of tumor cells, angiogenesis, tumor cell migration, invasion and metastasis either positively or negatively. Furthermore, some adhesion-GPCRs are considered potential biomarkers for specific types of cancers. In this review article, the expressional characteristics and functional role of cancer-associated adhesion-GPCRs are discussed in depth. |
本系統中英文摘要資訊取自各篇刊載內容。