頁籤選單縮合
題名 | 紅麴二次代謝物Monascin對小鼠巨噬細胞之抗發炎作用=The Anti-inflammatory Effect of the Monascus-Fermented Product Monascin on Murine Macrophages |
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作 者 | 黃韜; 徐瑋萱; 張郁瑩; 潘子明; | 書刊名 | 臺灣農業化學與食品科學 |
卷期 | 49:3 2011.06[民100.06] |
頁次 | 頁111-117 |
分類號 | 369.36 |
關鍵詞 | 紅麴; 抗發炎; Monascus; Monascin; Anti-inflammation; JNK; |
語文 | 中文(Chinese) |
中文摘要 | 本研究利用卵白蛋白(ovalbumin, OVA)處理小鼠巨噬細胞(RAW 264.7)以誘發發炎反應,並探討紅麴二次代謝物改善發炎之機制。紅麴黃色素(monascin)及OVA共同誘導24小時後,測定細胞激素(cytokines)表現量,證實tumor necrosis factor alpha (TNF-α)及interleukin 6(IL-6)皆顯著降低;進一步觀察發炎反應下游產物之生成量,發現monascin可抑制nitric oxide synthase(iNOS)及cyclooxygenase-2(COX-2)蛋白質表現因而減少nitric oxide(NO)及prostaglandin E(subscript 2)(PGE(subscript 2))之生成,並能抑制c-Jun NH2-terminal kinase(JNK)之磷酸化程度。綜合試驗結果得知,monascin有良好之抗發炎能力,具進一步開發為抗發炎藥物之潛力。 |
英文摘要 | The present study investigated the effect of the "Monascus"-fermented product, monascin, on inflammation caused by ovalbumin (OVA). Our purpose was to understand the anti-inflammatory mechanism of the monascin. In this study, the murine macrophage RAW 264.7 cells were co-treated with monascin and OVA for 24 hours. The results showed that cytokine expression, including tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), was obviously decreased. We further examined the expression of the downstream products of the inflammation pathway. Monascin had effectively inhibited the expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), thus decreasing the production of nitric oxide (NO) and prostaglandin E(subscript 2) (PGE(subscript 2)). It also down-regulated the phosphorylation of the c-Jun NH(subscript 2)-terminal kinase (JNK). These data suggested that monascin may have the potential to be developed as an anti-inflammation drug. |
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