查詢結果分析
相關文獻
- Development of Micropore-Controlled Release Tablet and In Vivo Pharmacokinetic Study
- 金屬射出成形用水溶性黏結劑之研究
- PEG分子量對射料流體性質的影響
- 有機藥劑前處理對透明塗裝木材光變色之抑制效應
- 臺灣雲杉(Picea morrisonicola Hay.)體胚發生與植株再生
- 聚嗍碸/聚乙二醇複合膜分離二氧化碳與甲烷混合氣體之研究
- 多陰離子性界面活性劑之研究(1)--合成及基本界面性質
- 雙性聚乙二醇接枝高分子的合成與性質
- Influence of Polymer Blending on Poly (ε-Caprolactone) Degradation
- Kinetics of Ozonation of Polyethylene Clycol In Printed Wiring Board Electroplating Solution
頁籤選單縮合
題 名 | Development of Micropore-Controlled Release Tablet and In Vivo Pharmacokinetic Study=微孔洞控釋錠的開發與動物體內藥物研究 |
---|---|
作 者 | 林文貞; 許家豪; | 書刊名 | Journal of Food and Drug Analysis |
卷 期 | 18:4 2010.08[民99.08] |
頁 次 | 頁263-268 |
分類號 | 418.631 |
關鍵詞 | 微孔洞控釋錠; 醋酸纖維素; 聚乙二醇; 藥動; Micropore-controlled release tablet; Theophylline; Cellulose acetate; Poly ethylene glycol; Pharmacokinetics; |
語 文 | 英文(English) |
英文摘要 | ABSTRACT The aim of this work was to develop a micropore-controlled release tablet for theophylline. The tablets were composed of a drug core surrounded by a microporous film. The major components of coating film included a biocompatible semipermeable polymer, cellulose acetate, and a water-soluble pore-forming agent, poly(ethylene glycol). The effect of the coating film composition and the type of excipient incorporated in the drug core on drug release were demonstrated via an in vitro release study. The optimized formulation was further investigated in vivo of rabbits. The results showed that micropore-controlled release tablets continuously released drug for 24-36 hours depending on the type of excipient in the drug core and the coating film composition. Incorporation of lactose in the drug core enhanced drug release from micropore-controlled release tablets. In vivo animal study revealed that the micropore-controlled release tablets reduced the maximum concentration and prolonged the mean residence time of drug. |
本系統中英文摘要資訊取自各篇刊載內容。