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題 名 | 回溯性分析某醫學中心肥胖病患Vancomycin藥物血中濃度監測結果=Retrospective Evaluation of Vancomycin Therapeutic Drug Monitoring in Obese Patients in a Medical Center |
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作 者 | 葉春蘭; 王慧瑜; 陳麗芳; | 書刊名 | 藥學雜誌 |
卷 期 | 26:4=105 2010.12[民99.12] |
頁 次 | 頁87-92 |
分類號 | 418.281 |
關鍵詞 | 藥物血中濃度監測; 分佈體積; 清除率; Ideal body weight; Total body weight; |
語 文 | 中文(Chinese) |
中文摘要 | 此研究探討我國肥胖病患使用 vancomycin適當的建議劑量,運用回溯性蒐集某醫學中心 95年1月至 98年4月腎功能正常, vancomycin藥物血中濃度監測結果在正常範圍之肥胖( BMI≧27 kg/m2)和正常體重( 18.5≦BMI<24 kg/m2)之患者,依據監測結果,比較兩者之間藥物動態學參數分佈體積、清除率和使用劑量之差異性,以進一步分析肥胖病患適當的建議劑量。 初步結果肥胖病患平均分佈體積較正常體重患者增加 17.7%(P<0.05),然而清除率和每日劑量兩者並無統計上差異,進一步分析其適當的建議劑量,結果發現肥胖病患每日劑量和理想體重的相關性優於和實際體重的相關性( r=0.441 vs 0.303,p< 0.05),此初步結果暗示著肥胖病患較適合使用理想體重建議劑量。 |
英文摘要 | The aim of this study was to determine an appropriate dose of vancomycin for Chinese obese patients in Taiwan. This is a retrospective study conducted at a medical center which has pharmacist-guided therapeutic drug monitoring programs.Patients with normal renal function and normal peak and trough concentration who received vancomycin between Jan 1, 2006 to April 30, 2009 were recruited and divided into two groups, obese subjects(BMI≧27 kg/m2)and normal weight control (18.5≦BMI<24 kg/m2).Pharmacokinetic parameters alteration were computed to compare the difference of volume of distribution, clearance between obese and normal weight patients, and to determine the appropriate vancomycin dose. In obese patients, the mean volume of distribution was increased 17.67% than the normal weight patients(P<0.05), however, no statistical change in mean clearance and vancomycin daily dose were reported in our study comparing obese and normal weight patients.The daily dose of vancomycin in obese patients have a better correlation with ideal body weight(IBW)than total body weight(TBW)( r=0.441 vs 0.303, p<0.05).These results implied that IBW should be used to calculate vancomycin doses for obese patients. |
本系統中英文摘要資訊取自各篇刊載內容。