查詢結果分析
相關文獻
- 雙重過濾血漿析離術過濾效能之比較--Kuraray KM8800及Asahi Plasauto iQ
- 雙重過濾血漿析離療法之血液學變化--每日及隔日療法之比較
- 雙重過濾血漿析離療法之血管通路研究--雙腔導管及周邊靜脈之比較
- 以免疫吸附血漿析離療法治療重症肌無力症之評估
- 重症肌無力症之免疫吸附血漿析離療法:免疫吸附管之吸附性能研究
- 血漿析離療法引起之凝血異常:一例報告
- 重症肌無力症之血漿析離療法
- Experience in the Treatment of Myasthenia Gravis with Double Filtration Plasmapheresis
- 高脂血症之雙重過濾血漿分離療法
- 由2004年臺灣北部--醫學中心血漿交換經驗談血漿析離之發展趨勢
頁籤選單縮合
題名 | 雙重過濾血漿析離術過濾效能之比較--Kuraray KM8800及Asahi Plasauto iQ=A Comparative Study of Filtration Efficacy in Double Filtration Plasmapheresis--Kuraray KM8800 versus Asahi Plasauto iQ |
---|---|
作者 | 沈幸梅; 葉建宏; 邱浩彰; Shen, Hsing-mei; Yeh, Jiann-horng; Chiu, Hou-chang; |
期刊 | 臺灣醫學 |
出版日期 | 19990700 |
卷期 | 3:4 1999.07[民88.07] |
頁次 | 頁367-372 |
分類號 | 415.9 |
語文 | chi |
關鍵詞 | 血漿析離術; 雙重過濾血漿析離術; 血清蛋白質清除率; 血漿分離器; 血漿成份分離器; 穿膜壓; Plasmapheresis; Double filtration plasmapheresis; Removal rate of serum protein; Plasma separator; Plasma fractionator; Transmembrane pressure; |
中文摘要 | 雙重過濾血漿析離療法 (double filtration plasmapheresis,DF) 可以半選擇 性除去血中乙醯膽鹼受體抗體,而改善重症肌無力病人之重度無力現象。 DF 療法之療效完 全取決於血漿分離器及血漿成份分離器之過濾效能。我們以 DF 療法治療 24 例重度重症肌 無力病患, 其中 16 例採用 Kuraray 公司之 KM8800 血漿分離機, 另 8 例則採用 Asahi 公司之 Plasauto-iQ 血漿分離機。 治療中我們連續監測血流速度、動脈壓、靜脈壓,及穿 膜壓以期了解血漿分離器之過濾效能。另於療程前後各檢測血中蛋白質濃度,包括白蛋白、 球蛋白、免疫球蛋白、膽固醇、脂蛋白、三酸甘油脂和血球計數,以評估血漿成份分離器之 過濾性能。 DF 治療中,穿膜壓逐漸上升,而其它動脈壓,靜脈壓,及血流速度則相對穩定 。比較兩組可以發現,Asahli 組之治療初期穿膜壓與動脈壓略低於 Kuraray 組 (p<0.001) 。唯在過高之全程穿膜壓 (壓力 >50mmHg) 及溶血發生率上,兩組未見顯著差異。至於血漿 中免疫球蛋白 G 及免疫球蛋白 A 的清除率, 在 Kuraray 組略高於 Asahi 組, 分別是 65.4% vs. 45.6%,(p<0.005) 及 72.7% vs. 55.7%,(p<0.001)。因此,兩組間初期穿膜壓 之差異應與動脈壓之差異有關,而與血漿分離器設計應無直接相關。至於血漿物質之清除率 ,血漿成份分離器之膜面積應是一重要之決定因素。 |
英文摘要 | Double filtration plasmapheresis (DF) alleviates the profound weakness of patients with myasthenia gravis (MG) , by semiselectively removing acetylcholine receptor antibodies. The efficacy in DF depends on the functional capacity of both the plasma separator and the fractionator. We treated 24 MG patients with DF, using either the Kuraray KM 8800 (Kuraray Co., Osaka, Japan) (n=16) or the Asahi Plasauto iQ (Asahi Medical Co., Tokyo, Japan) (n=8) plasmapheresis monitor. To evaluate the filtration efficacy of plasma separators, we monitored the blood flow rate (BF), arterial pressure (PA), venous pressure (PV) , and transmembrane pressure (TMP) serially during treatment. To assess the efficiency of the plasma fractionators, we measured levels of the serum proteins, including albumin and globulin, immunoglobulin (Ig) G, IgA, IgM, cholesterol, lipoproteins, and triglycerides, and obtained complete blood counts, before and after plasmapheresis therapy. The TMP rose gradually and the PA, PV, and BF were relatively constant during DF treatment. The initial TMP and PA were significantly lower (p<0.001) in the Asahi group than the Kuraray group. However, the percentage of patients with unsatisfactory TMP levels (TMP > 50 mmHg) and hemolysis were not significantly different between the two groups. The median removal rate of IgG and IgA were significantly higher in the Kuraray group (65.4% vs 48.6%, (p< 0.005); and 72.7% vs 55.7%, (p<0.00l), respectively). The differences in the TMP changes between the two groups may be related to the changes in the PA itself rather than the column design. As for the removal rate of serum protein, the surface membrane of the plasma fractionator may be a crucial factor in the treatment of DF. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。