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| 題 名 | Chronic Cadmium Toxicity in Rats: Treatment with Combined Administration of Vitamins, Amino Acids, Antioxidants and Essential Metals=大鼠慢性鎘中毒實驗:合併給予維生素,氨基酸,抗氧化劑和必需金屬處置 |
|---|---|
| 作 者 | Gaurav, Deepti; Preet, Shabad; Dua, K. K.; | 書刊名 | Journal of Food and Drug Analysis |
| 卷 期 | 18:6 2010.12[民99.12] |
| 頁 次 | 頁464-470+474 |
| 分類號 | 411.3 |
| 關鍵詞 | 膳食營養素; 脂質過氧化; 氧化應激; 抗氧化防禦系統; 鎘; Dietary nutrients; Lipid peroxidation; Oxidative stress; Antioxidant defense system; Cadmium; |
| 語 文 | 英文(English) |
| 中文摘要 | 本研究以 albino雄性大鼠為實驗動物,探討膳食營養素對鎘引起之肝,腎毒性的保護作用。大鼠隨機分為 11組,對照組 Group I給予口服生理食鹽水,Group II給予氯化鎘 2 mg/kg皮下注射。其餘各組 (Group III、IV、V、VI、VII、VIII、IX) 給予 10 mg/kg膳食營養素,分別為維生素 B1,蛋氨酸, N-乙醯半胱胺酸 (NAC),褪黑激素,鋅,維生素 E,胱氨酸。Group X給予 0.1 mg/kg劑量的硒 (Se),Group XI則合併給予 NAC、鋅,維生素 B1和褪黑激素,所有的處理組均為口服三週,伴隨皮下注射鎘。鎘中毒大鼠肝,腎毒性表現於脂質過氧化程度和 superoxide dismutase、 glutathione peroxidase、alkaline phosphatase活性、總蛋白等數值明顯下降。相對於單獨給予各種膳食營養素,合併給予蛋氨酸,鋅,維生素 B1和 NAC,更能改善鎘引起的脂質過氧化和氧化壓力,因為顯著地啟動抗氧化防禦機制,因此對鎘引起的肝、腎毒性具保護作用。 |
| 英文摘要 | The present study was designed to investigate the protective effect of dietary nutrients against cadmium-induced hepatic and renal toxicities in male albino rats. The animals were randomly divided into eleven groups where the control group (Group I) received physiological saline (p.o.) and Group II was administered with cadmium chloride (2 mg/kg, s.c.) only. Groups III, IV, V, VI, VII, VIII and IX received 10 mg/kg dietary nutrients, i.e. thiamine, methionine, N-acetylcysteine (NAC), melatonin, zinc (Zn), vitamin E and cystine, respectively. Group X received a dose of 0.1 mg/kg of selenium (Se) and Group XI was administered with a combination of NAC, Zn, vitamin B1 and melatonin. All treatments were administered orally for 21 days with a concomitant subcutaneous (s.c.) cadmium treatment. Cadmium-intoxicated rats exhibited hepatic and renal toxicities as indicated by elevation of lipid peroxidation and marked decline in superoxide dismutase, glutathione peroxidase, alkaline phosphatase activities and total protein. However, a combined treatment with dietary nutrients, i.e. methionine, zinc, vitamin B1 and N-acetylcysteine ameliorated cadmium-induced lipid peroxidation and oxidative stress as they provoked the antioxidant defense system more significantly, when compared to each of them alone and hence is suggested as protective against cadmium-induced hepatic and renal toxicities. |
本系統中英文摘要資訊取自各篇刊載內容。