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題名 | Dibenzoylmethane Altered Adipose Mass, Serum Lipid and Sex Steroid Hormone in Female Mice=二苯甲醯基甲烷對雌性小鼠脂肪組織質量、血液中脂質及性荷爾蒙含量之影響 |
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作者姓名(中文) | 林娟娟; 黃茂端; 何其儻; | 書刊名 | Journal of Food and Drug Analysis |
卷期 | 18:5 2010.10[民99.10] |
頁次 | 頁339-345+368 |
分類號 | 341.91 |
關鍵詞 | 二苯甲醯基甲烷; 脂質代謝; 三酸甘油脂; 雌二醇; 乳腺腫瘤; Dibenzoylmethane; Lipid metabolism; Triglyceride; Estradiol; Mammary tumorigenesis; |
語文 | 英文(English) |
英文摘要 | ABSTRACT Dibenzoylmethane (DBM), a β-diketone structural analogue of curcumin, has been reported to exhibit anti-tumorigenic and chemopreventive activities in mouse mammary tumorigenesis. Our previous study indicated that DBM modulates estrogenic action both in vitro and in vivo. In this report, the potential role of DBM as modulator of lipid metabolism in two mouse models was investigated. Several biomarkers and intermediate metabolites related to lipid consumption were measured. The results indicated that the parametrial fat pad weight, the level of triglyceride in both CD-1 and Sencar mice fed with 1% DBM, was remarkably reduced. In addition, the estradiol level, uterus and mammary gland weights were significantly decreased in CD-1 and young Sencar mice at 55 days of age (during the estrous phase of estrous cycle). The reduction of both estradiol level and triglyceride in serum would explain the inhibitory effect of DBM on mammary tumorigenesis as a modulator in dietary lipid metabolism. |
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