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題名 | Blood Lipid Distrbution in Patients with Newly-Diagnosed, Non-Insulin-Dependent Diabetes Mellitus=新診斷非胰島素依賴型糖尿病患之血脂肪分析 |
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作者 | 曾立年; 許惠恆; 張文瀚; 宋育民; Tseng, Li-nien; Sheu, Wayne Huey-herng; Cheung, Bruno Man-hon; Song, Yuh-min; |
期刊 | Acta Cardiologica Sinica |
出版日期 | 19980400、19980500、19980600 |
卷期 | 14:2 民87.04-06 |
頁次 | 頁58-63 |
分類號 | 415.937 |
語文 | eng |
關鍵詞 | 高膽固醇血症; 高三酸甘油脂血症; 冠狀動脈心臟病; 新診斷非胰島素依賴型糖尿病; Hypercholesterolemia; Hypertriglyceridemia; Coronary heart disease; Newly diagnosed; Non-insulin-dependent diabetes mellitus; |
中文摘要 | 背景:糖尿病患心血管疾病之罹病率、死亡率均明顯的增加,而血膽固醇值是心血管疾病之一重要指標,降低血膽固醇可明顯降低心血管疾病之發生率及死亡率。本研究係為探討新診斷第二型糖尿病患之血脂分佈情形,以期進一步預防心血管疾病之發生。 方法與結果:本研究自民國83年7月至84年6月,由5206位住入台中榮民總醫院體檢中心的成人收集了76例(男42位,女34位)新診斷第二型糖尿病患,這些病患受檢前皆沒有血糖異常病史,但此次檢查結果符合聯合國衛生組織對糖尿病的診斷。另在同一時段內本研究亦收集了73例(男38位,女35位)無血精異常病史且此次體檢飯前、飯後血糖完全正常者為對照組。結果顯示新診斷第二型糖尿病患血膽固醇過高(≧240mg/dL)及血三酸甘油脂高(≧200mg/dl)者之比例比對照組明顯增高。依照美國國家膽固醇教育計劃第二次成人治療座談會之建議,有54%之新診斷第二型糖尿病患需作進一步脂蛋白分析。經脂蛋白分析,有47.4%的新診斷第二型糖尿病患需開始積極治療,包括低密度脂蛋白膽固醇≧160mg/dL者及低密度脂蛋白膽固醇在130-159mg/dL並併有兩個以上冠狀動脈心臟病危險因子者;此一心例亦比對照組明顯增高。 結論:除了血三酸甘油脂較高外,新診斷第二型糖尿病患有高比例的高膽固醇血症,而糖尿病本身亦是冠狀動脈心臟病之一危險因子,糖尿病患應積極控制血糖及血脂異常,以降低心血管疾病之發生率及死亡率。 |
英文摘要 | Background: Numerous investigations have revealed that diabetes markedly increases mortality and morbidity from cardiovascular complications. Serum cholesterol levels have been shown to be a predictor of coronary heart disease (CHD), and reduction of serum cholesterol concentrations markedly decrease the incidence and mortality of CHD. The purpose of this study was to investigate the blood lipid distribution in patients with newly-diagnosed, untreated, non-insulin-dependent diabetes mellitus (NIDDM). Methods and Results: A total of 76 persons (42 men, 34 women ), with newly-diagnosed NDDM, were obtained from 5,206 adults who were admitted to The Physical Check-up Center of The Taichung Veterans General Hospital from July 1994 to June 1995. Results of blood lipid measurements were analysed according to the guidelines of The National Cholesterol Education Program( NCEP) (U.SA.), Adult Treatment Panel II (ATP II). The percentage of high blood cholesterol ( ≧240 mg/dl ) was significantly higher in the newly-diagnosed NIDDM group. Fifty-four percent of patients with newly-diagnosed NIDDM required lipoprotein analysis which was significantly higher than that in the control group. Forty-seven percent of newly-diagnosed NDDM subjects including those with LDL-cholesterol l60mg/dL or LDL-cholesterol 130-159 mgldb, with 2 or more CHD risk factors required to initiate aggressive therapy according to the recommendations of NCEP, ATPII. The percentage warranting therapy was significantly higher in the newly-diagnosed NIDDM group. The percentage of hypertriglyceridemia was also significantly higher in the newly-diagnosed NIDDM subjects. Conclusion: Patients with newly-diagnosed NIDDM have high rates of hypertriglyceridemia, hypercholesterolemia and borderline-high to high-risk LDL-cholesterol which require initiation of aggressive therapy. Patients with NIDDM should seek more rigid glycemic and blood lipid control in order to decrease the incidence and mortality of CHD. |
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