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題 名 | Potential Function of Amniotic Fluid in Fetal Development - Novel Insights by Comparing the Composition of Human Amniotic Fluid with Umbilical Cord and Maternal Serum at Mid and Late Gestation=羊水對胚胎發育的潛在功能-從比較人類孕中晚期同一母體羊水、臍帶血清及孕母血清組成得到的新啟示 |
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作 者 | 童興隆; 王玲; 高垣兵; 秦玉國; 祁玉巧; 許彥平; | 書刊名 | Journal of the Chinese Medical Association |
卷 期 | 72:7 2009.07[民98.07] |
頁 次 | 頁368-373+CA68 |
分類號 | 417.131 |
關鍵詞 | 羊水; 組成; 胎兒; 蛋白質; 腫瘤標誌物; Amniotic fluid; Composition; Fetus; Protein; Tumor marker; |
語 文 | 英文(English) |
英文摘要 | Background: Amniotic fluid (AF) is a dynamic and complex mixture. Up to now, little is known about the physiological functions of AF in the process of fetal development. We suppose that AF carries components such as proteins or peptides, which contribute to the regulation of fetal development. Methods: Compositions including biochemical components and tumor markers were determined in human AF, umbilical cord serum (UCS) and maternal serum (MS) from the same subject in the range of 15–42 weeks of gestation. Results: (1) The levels of primary electrolytes such as sodium, chloride, anion gap and osmotic pressure in AF was almost the same as in UCS and MS. (2) The levels of organic substances, including total protein, glucose, triglycerides, cholesterol and various enzymes, were markedly lower in AF than in UCS and MS, especially for total protein, which was 8- and 12.5-fold lower in AF than in UCS and MS, respectively. (3) The levels of tumor markers, including carcinoembryonic antigen, ferritin, cancer antigen 125 and 199, and α-fetoprotein in AF displayed different dynamic changes compared to UCS and MS as gestation advanced. Conclusion: This study demonstrated that AF is not a result of simple filtration from the blood but an independent fluid. We speculate that proteins or peptides in the amniotic fluid modulate the process of fetus development since they possess potent bioactivity on cellular growth and proliferation. AF provides a pathway to transport these “regulators” to the fetus and thus plays a pivotal role in fetal development. |
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