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題名 | 不同均質機製備奈米微脂粒磷酸鎂之研究=A Study of Different Homogenizer Preparing for Magnesium Acorbyl Phosphate Incorporated in Nano-liposomes |
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作者姓名(中文) | 徐珮清; 陳崇裕; | 書刊名 | 慈惠學術專刊 |
卷期 | 3 2007.10[民96.10] |
頁次 | 頁200-211 |
分類號 | 466.7 |
關鍵詞 | 微脂粒; 維生素C磷酸鎂; |
語文 | 中文(Chinese) |
中文摘要 | 微脂粒在藥物攜帶上的應用已有長遠歷史,應用在化妝品工業上卻是近幾年才開始。微脂粒分子膜與皮膚分子結構極為相似,利用微脂粒來攜帶活性成分,可有效的送至皮膚深層。本實驗嘗試利用均質機及高速微射流均質機製備維生素C磷酸鎂之樣品。實驗製備分三組,一組使用均質機,轉速設為19,000轉,時間5分鐘。另外兩組使用高速微射流均質機製備,均質機壓力設定為700bar,將循環設定為10 cycles製備一組,另一組設定循環為20 cycles。製備完成後,對製備出之三種樣品進行一系列之特性評估,包括粒徑大小、包覆率、穩定性、安全性,以及釋出率等。研究結果顯示,本實驗製備出之微脂粒粒徑大小約在0.5-1.1μm之間,以高速微射流均質機,用20循環所製備的微脂粒粒徑最小,粒徑515μm。利用微脂粒來攜帶維生素C磷酸鎂是可行的。三種樣品的包覆率約在的-52%。以均質機製備的樣品包覆率較高。在安全測試上,人體貼布並無任何過敏或不適合之症狀。在體外釋出上,利用溶離實驗所測得數據,顯示三種樣品在24小時溶離中,以定速慢慢釋放出包埋物,在滲透度上, 24小時後三種樣品無顯著性差異。 |
英文摘要 | It has been a long history since liposome as a drug carrier was applied in the medical applications. However, it is a new concept for the cosmetic industry in the recent years. Due to the similarity of chemical structures between liposome and human skin, it is easier for liposome to carry an active agent that is necessary for skin cells and help the agent to penetrate through skin deeply. The study was trying to create a type of liposome that will carry Magnesium Ascorbyl Phosphate (MAP) as an active agent by using two equipments - the ultra homogenizer and the Microfluidizer. Three different kinds of liposomes were made. One was manufactured by the ultra homogenizer with rotation speed 19,000, and duration time was 5 minutes. The other two were made by the Microfluidizer with pressure setting at 700 bar. One of them was made with 10 cycling times. The other was with 20 cycling times. Once these liopsomes are created in the lab, they will be measured by size and drug entrapment efficiency. Also the liposomes will be evaluated with stability and transdermal permeation in vitro via dissolution test. The final result indicates that the size of the liposome is about 0.5-1.1μm. The smallest one, whose size is about 515 nanometers, was made by the Microfluidizer with 20 cycling times. It is proved that a liposome is capable of carrying MAP as its content. Our results also show that the drug entrapment efficiency is about 43-52%. Liposomes made by the ultra homogenizer have the higher entrapment efficiency. In safety test, it shows no sign of allergy. And the dissolution test indicates that MAP was released from the liposome at the same speed, and there is no significant difference among all three samples after 24 hours. |
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