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頁籤選單縮合
題名 | Norepinephrine Transporter Inhibitors from Polygala Tenuifolia=分離自中藥遠志之具有正腎上腺素轉運子抑制活性之化合物 |
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作者姓名(中文) | 林雲蓮; 陳婉屏; 柯漢傑; 柯逢年; 吳天賞; | 書刊名 | 藥物食品分析 |
卷期 | 16:3 2008.06[民97.06] |
頁次 | 頁26-30+90 |
分類號 | 418.52 |
關鍵詞 | 酚性醣苷; 遠志; 正腎上腺素轉運子抑制劑; 皂素; xanthone醣苷; Polygala tenuifolia; Norepinephrine transporter inhibitor; Saponins; Xanthone glycosides; Phenolic glycosides; |
語文 | 英文(English) |
英文摘要 | Using norepinephrine transporter binding assay-directed fractionation, polygalasaponin XXVIII (1) and 3-O-β-D-glucopyranosyl presenegenin 28-[O-β-D-galatopyranosyl(1→4)-β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl(1→2)-β-D-fucopyranosyl] ester (2), together with five xanthone glycosides, neolancerin (3), polygalaxanthone IX (4), sibiricaxanthone (5), polygalaxanthone III (6), and 7-O-methylmangiferin (7), five phenolic glycosides, tenuifoliside A (8), sibiricoses A3 (9), A5 (10), A6 (11) and 3’,6-disinapoyl sucrose (12), a triterpenoid, tenuifolin (13), methyl sinapoate (14), and adenosine (15) were isolated from the active fraction of an aqueous extract of the roots of Polygala tenuifolia. Their structures were elucidated by extensive NMR and mass spectroscopic analyses. Compounds 1 and 2 were shown to inhibit norepinephrine reuptake through blocking norepinephrine transport by 77% and 28% in the norepinephrine transporter binding assay at concentrations of 4.53 μM and 3.95 μM, respectively. |
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