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頁籤選單縮合
題名 | Retrospective Investigation of Serological Markers and Clinical Characteristics in Neonatal Lupus Syndrome=回溯性地分析新生兒紅斑症候群病人的血清標記與症狀 |
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作者 | 徐永明; 揚生湳; 黃崇濱; 黃新純; | 書刊名 | Clinical Neonatology |
卷期 | 14:1 2007.06[民96.06] |
頁次 | 頁19-22 |
分類號 | 417.517 |
關鍵詞 | 新生兒; 紅斑症候群; 血清標記; Neonatal lupus syndrome; Platelet count; GOT; |
語文 | 英文(English) |
英文摘要 | Neonatal lupus syndrome (NLS) is a rare syndrome occurring in the first six months of life. It is characterized by the presence of autoantibodies and cardiac, hematologic, dermatologic, hepatobiliary or neurologic manifestations in affected infants. Congenital heart block is irreversible, while noncardiac manifestations are transient. In this retrospective study, medical records of 23 infants who were positive for autoantibodies from 1991 to 2004 were reviewed. Twenty-two infants who showed at least one of the typical manifestations of NLS were enrolled in the study. A negative correlation between the platelet count and glutamic oxaloacetic transaminase (GOT) level was found. In the literature, anti-SSA/Ro has been associated with congenital heart block and neutropenia. Our results showed that anti-SSA/Ro was not contributory to thrombocytopenia or elevation of aminotransferases. We presume that an autoantibody or some event may be contributory to both the pathogenesis of thrombocytopenia and elevation of aminotransferases. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。