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題名 | Blockade of Spinal Nitric Oxide Synthase on Blood Pressure Variability and Hepatic Microcirculation=抑制脊髓一氧化氮酶對血壓變異性和肝臟微循環之作用 |
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作者 | 陳智宏; 石明煌; | 書刊名 | 麻醉學雜誌 |
卷期 | 43:2 民94.06 |
頁次 | 頁67-72 |
分類號 | 416.5 |
關鍵詞 | 自主神經系統; 微循環; 一氧化氮; 脊髓; 大白鼠; Autonomic nervous system; Microcirculation; Nitric oxide; Spinal cord; Rats; |
語文 | 英文(English) |
中文摘要 | 背景:本實驗室過去發現,椎管內注射一氧化氮酶阻斷劑N(上標 G)-nitro-L-arginine methyl ester (L-NAME)會引起血壓增高,而且隨使用劑量成正比。本研究目的是使用血壓訊號頻譜分析來探討自主神經參與其中的角色,同時探討椎管內注射一氧化氮酶阻斷劑對肝臟微循環的作用。方法:本實驗使用八隻Spraque-Dawley大鼠,以ketamine 120 mg/kg腹腔注射誘導及30 m/kg/h靜脈滴注維持麻醉。手術準備包括右股動脈及靜脈導管植入,分別用作記錄血壓訊號和給藥,我們在大鼠身上進行迷你開腹手術,同時在肝臟中葉植入微透析管及置放雷射杜卜勒探針測量其微循環參數,實驗時,於椎管內間隔兩小時注射L-NAME,劑量分別是0、0.37、0.74、和1.48μmol。結果:隨注射之劑量增加血壓呈正向增高。同時,代表血管運動張力的血壓頻譜極低頻其強度也隨劑量增高,而代表自主神經平衡的低頻與高頻比值則遞減,表示此時感壓反射起動而副交感神經較強,微透析測得代表肝臟代謝功能的monoethylglycinexylidide (MEGX)此時並未改變,杜卜勒血流量在低劑量0.37 μmol時稍減少,但一般均呈穩定狀態。結論:在本實驗中,我們認為阻斷脊髓內一氧化氮酶活性會增高血管運動張力,進而增高動脈血壓,感壓反射不受脊髓內一氧化氮酶活性抑制所影響仍可起動,交感神經抑制,副交感神經相對強勢。此時的肝臟微循環則不太受到影響而相當穩定。 |
英文摘要 | Background: We previously demonstrated that intrathecal administration of N(superscript G)-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor; increased systemic arterial blood pressure in a dose-dependent manner in rats. The aim of the study was to investigate the participation of autonomic nervous system on L-NAME-induced hypertension and also illuminate its effects on hepatic microcirculation in rats. Methods: Eight Spraque-Dawley rats were used and initially anesthetized with ketamine 120 mg/kg, intraper-itoneally supplemented by intravenous infusion of ketamine at 30 mg/kg/h for maintenance. Surgical preparations included cannulations of right femoral artery and vein to obtain systemic arterial pressure signals and administer anesthetic drug. A mini-laparotomy was made to facilitate the insertion of a microdialysis probe and attachment of a laser Doppler probe to the middle lobe of the liver. On experiment, L-NAME was administered via the previously placed intrathecal catheter at 0, 0.37, 0.74, and 1.48 μmol in sequence at a 2-h interval. Results: The results showed that the arterial blood pressure increased in a dose-dependent manner. By the same token, the power density of very low frequency (VLF) also increased. The low frequency (LF): high frequency (HF) ratio shifted toward parasympathetic dominance. Blood flow to the liver was unchanged except slightly decreased in the animals receiving 0.37 μmol. The levels of monoethylglycinexylidide (MEGX), an index of hepatic metabolism, were unchanged throughout the experiment. Conclusions: We concluded that the blockade of spinal nitric oxide synthase by intrathecal administration of L-NAME significantly increased vasomotor tone in a dose-dependent manner and as a consequence induced a reflex sympathetic inhibition. Hepatic microcirculation was stable with the applied doses. |
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