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題名 | The Antinociceptive and Anti-inflammatory Effects of a Long-acting Depot Formulated Ketorolac in Rats=一個含非類固醇消炎劑之長效藥物貯存劑型-- Ketorolac苯酯在大白鼠之止痛與抗發炎測試 |
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作者 | 曾劍英; 褚錦承; 馮炳勳; 侯佳慧; 謝介平; 何善台; 王志中; | 書刊名 | 麻醉學雜誌 |
卷期 | 43:1 民94.03 |
頁次 | 頁17-22 |
分類號 | 416.5 |
關鍵詞 | 疼痛; 非類固醇消炎劑; 酯; 長效製劑; Pain; Anti-inflammatory agents, non-steroidal; Esters; Ketorolac; Long-acting preparations; |
語文 | 英文(English) |
中文摘要 | 背景:目前在臨床上並無長效之非類固醇消炎劑可供治療為期較長的疼痛,本研究的目的在探討一個內含ketorolac苯酯的新藥物貯存劑型是否具有長效的消炎及止痛作用。方法:我們以大白鼠來進行二項實驗。實驗一:我們測量肌肉注射傳統劑型ketorolac trome-thamine水溶液的消炎及止痛作用。實驗二:我們測量肌肉注射含ketorolac苯酯之新油性劑型的消炎及止痛作用。止痛作用以腳掌壓力試驗來測試,消炎作用以腳掌腫脹試驗來測試。結果:我們發現肌肉注射傳統ketorolac tromcthamine 水劑24, 80及240μmol/kg產生了顯著的止痛及消炎作用,但其效期僅有6-8小時。而肌肉注射新的ketorolac苯酯油劑240μmol/kg卻產生了56小時的止痛及消炎作用。結論:在大白鼠以肌肉注射ketorolac苯酯之油劑可產生一個非常長的止痛及消炎作用,其效果為傳統ketorolac tromethamine水劑的7倍長。 |
英文摘要 | Background: Currently, no long-acting nonsteroidal anti-inflammatory drug is available clinic ally for the treatment of long-lasting pain. The aim of the study was to evaluate the antinociceptive and anti-inflammatory effects and duration of action of a novel depot formulation of ketorolac benzyl ester in sesame oil. Methods: Two studies in Sprague-Dawley rats we re carried out. In study 1, the antinociceptive and anti-inflammatory effects of intramuscular ketorolac tromethamine were evaluated. In study 2, the antinociceptive and anti-inflammatory effects of intramuscular ketorolac benzyl ester were evaluated. The antinociceptive effect was evaluated using the paw pressure test, whereas the anti-inflammatory effect was evaluated by the paw edema test. Results: Intramuscular ketorolac tromethamine at 24, 80, and 240μmol/kg (in saline) produced significant anti-nociceptive and anti-inflammatory effects with duration of action around 6 to 8 h. Ketorolac benzyl ester at a dose of 240μmol/kg (in oil) produced significant long-acting antinociceptive and anti-inflammatory effects with duration of action of 56 h. Conclusions: Intramuscular injection of ketorolac benzyl ester (in sesame oil) in rats produced antinociceptive and anti-inflammatory effects which we re 7-fold longer in duration of action than ketorolac tromethamine (in saline). |
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