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頁籤選單縮合
題名 | Injection Pain with Propofol: The Effectiveness of Thiopentone on Induction=關於Propofol注射產生之疼痛:在誘導時使用Thiopentone的效果 |
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作者 | 程廣義; 湯兆舜; 邱舜麗; 陳太乙; 王建仁; 范國棟; 余廣亮; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷期 | 14:8 1998.08[民87.08] |
頁次 | 頁480-485 |
分類號 | 416.5 |
關鍵詞 | 疼痛; 麻醉科; Pediatric; Propofol; Thiopentone; |
語文 | 英文(English) |
中文摘要 | 127位年齡3至6歲的兒童被分成四組,並在手背上安置靜脈注射。於麻醉誘導時, L1、 L2 和 L3 三組病童均接受 propofol 3 mg ╱ kg 分別混合 lignocaine 0.15 mg ╱ kg、 0.3 mg ╱ kg 和 0.6 mg ╱ kg。 T 組則先接受 thiopentone 3 mg ╱ kg, 再施以 propofol 1.5 mg ╱ kg 混合 lignocaine 0.075 mg ╱ kg。注射 propofol 產生的疼痛被 分成兩個類別(臉部表情及肢體回縮)臉部表情再次分為無、輕度(皺眉頭)、中度(扮鬼 臉)和重度反應(哭叫),肢體回縮亦次分為無、輕度(手掌回縮)、中度(手臂及前臂回 縮)和重度反應(手臂回縮及身體扭曲)。所有病童均監視以心電圖、脈博血氧定量計、全 自動非侵入性血壓測量計、和二氧化碳監測器。結果:四組病童在特徵上並無明顯差異。注 射疼痛在 L1 組病童( 81 %)明顯多於 T 組( 27 %),且有統計差異( P < 0.05 ) 。增加 lignocaine 劑量會降底中度和重度疼痛級數的發生率,且興奮反應的發生率會在 T 組和隨著 lignocaine 劑量增加而降低,但是無統計上的差異。 結論:Thiopentone可被用來降低propofol注射疼痛。 |
英文摘要 | One hundred and twenty-seven children aged 3-6 years were allocated to four groups. All of them received venous cannulation on the dorsum of the hand. On induction, the group L1, L2 and L3 patients received propofol 3mg/kg mixed with lignocaine 0.15mg/kg, 0.3mg/kg, 0.6mg/kg, respectively. The group T patients received thiopentone 3mg/kg, then propofol 1.5mg/kg mixed with lignocaine 0.075mg/kg. Pain on injection was categorized into two-assessment items (facial expression and limbs withdrawal). The facial expression category were subdivided into none, mild (knit of brows), moderate (grimace), and severe (crying). The withdrawal of limbs was categorized into none, mild (withdrawal of hand), moderate (withdrawal of forearm and arm), severe (withdrawal of arm and twisting of body). Patients were monitored using an electrocardiogram, pulse oximeter, autonomic noninvasive blood pressure measuring device and capnography. The patient characteristics did not differ significantly among the four groups. Pain on injection was significantly more frequent in the group L1 patients (81%) compared with the group T (27%) patients. Increasing lignocaine dose reduced the incidence of pain graded as "moderate" or "severe" though there was no significant difference. The incidences of excitatory effect on propofol injection were reduced with increasing lignocaine dose and prior administration of thiopentone but there were no obviously differences among groups. We concluded that thiopentone reduced injection pain on propofol and should be recommended. |
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