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題名 | 中藥材黃連併用於惡性腫瘤放射線治療之輔助性功能研究=Adjunct Therapeutic Effect of Chinese Herb Coptis Chinensis in Combination with Radiotherapy on Cancer |
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作者 | 成佳憲; Cheng, Chia-hsien; |
期刊 | 中醫藥年報 |
出版日期 | 20071000 |
卷期 | 25:1 2007.10[民96.10] |
頁次 | 頁257-285 |
分類號 | 418.5 |
語文 | chi |
關鍵詞 | 中藥材; 黃連; 放射線治療; 腫瘤輔助性治療; Chinese herb; Coptis chinensis; Radiotherapy; Cancer adjuvant therapy; |
中文摘要 | 放射線治療為探討中藥材在腫瘤治療輔助性角色應用上最佳的模式。主要原因包括放射線為安全性高的非侵入性治療,而且本身即具有一定的治療效果,不必考慮測試藥物產生不可預知的作用。腫瘤放射線治療過程中如何增強腫瘤細胞對放射線治療的感受性,與減低對正常組織的損傷,是極需解決的兩大問題。發炎反應是目前被研究認為同時與這兩個問題有最大的關聯性的生理反應,也就是反射線治療引發的發炎反應可能對腫瘤細胞有利但卻對正常組織有害。在中藥材中亦有許多被公認具有良好抗發炎效果的藥材,這些藥材以長期服用的考量上其在副作用可能比西藥更小,因此只要再予以科學性的研究建立適切的理論基礎將對於運用於腫瘤輔助性治療有很大的發展潛力。本計畫所提之黃連在傳統上及現代的研究中都被證實具有抗腫瘤、抗血管新生、抗發炎、殺菌等作用。學理上而言,十分適合運用於抑制腫瘤放射線治療引發的發炎反應的輔助性治療。本計畫所提出之中藥材黃連,組成份已在各個領域明確的被研究分析出,使得其作用機轉與藥理作用易於被科學性的驗証,本計畫運用本實驗室在腫瘤放射治療之研究模式,由先測試動物模式的有效性再進入機轉探討。包含第一部分為利用動物模式探討黃連及黃連萃取物對於腫瘤放射線治療的輔助性效果,以腫瘤生長曲線及動物血清中發炎反應分子IL-6及PGE-2的變化為評估標準,結果呈現黃連及黃連萃取物雖無法使放射線對腫瘤的控制有更多的加強,但確實造成動物血清發炎反應分子的降低。第二部分為利用細胞模式探討黃連及黃連萃取物是否改變腫瘤細胞與正常細胞對放射線處理的敏感性,結果呈現黃連及黃連萃取物並未增加腫瘤細胞的放射線敏感性。第三部分為利用血管內皮細胞模式探討黃連萃取物是否改變VEGF對血管內皮細胞的各種血管新生效應,結果呈現黃連較黃連萃取物更能改變VEGF對血管內皮細胞的通透性與移行能力。第四部分為利用分子生物學方法探討黃連萃取物是否改變腫瘤細胞與正常細胞受放射線處理時細胞內重要的訊息傳遞分子的活化,以PI3K/Akt、MAPK/p38、MAPK/ERK的磷酸化變化及轉譯分子NFk-B及HIF的leuciferase reporter activity變化為評估標準,結果呈現黃連較黃連萃取物更能抑制訊息傳遞分子的活化,但效果有限。由於黃連係混合物且黃連主要萃取物效果均不如黃連的綜合效果,未來應朝向分析黃連主要萃取物以外的其他成份應用於輔助腫瘤放射線治療的可行性及其分子機轉。 |
英文摘要 | Radiation biology experiment is the best model for the adjunct therapeutic test, because of its safe, noninvasive characteristics and effectiveness. In radiation model we do not have to consider the interaction between the test drug and the other drugs. In radiation biology for cancer, the ways to enhance cancer cell sensitization and to reduce the damage of normal tissue from radiation are the most important issues to be addressed. Inflammation is being highly recognized as one of the keys to these two physiological responses. On the other hand, radiotherapy induced inflammation may be beneficial for tumor cells but harmful for normal tissue. This concept has been accepted and several clinical trials of anti-inflammatory drug combined radiotherapy are ongoing. Chinese herb Coptis chinensis has been used for anti-inflammation and anti-bacterial traditionally. We tested its potential role of adjunct therapeutic effect in combination with radiotherapy on cancer treatment. In this study we investigated the adjunct therapeutic effect of Coptis chinensis in an animal model and evaluate the anti-inflammation effect by detecting serum level IL-6 and PGE2. We found that Coptis chinesis did not enhance radiation related tumor control, but was associated with the suppression of inflammatory markers in serum. Radiosensitization effect on cancer cells and normal cells from Coptis chinensis and its extracts was not shown. These herbs and extracts were not cytotoxic. Coptis chinensis showed more effects than its extracts on VEGF mediated HUVEC angiogenic response, permeability, migration and tube formation. Coptis chinensis partially inhibited radiation induced signal transduction mediators such as PI3K/Akt, MAPK/P38, MAPK/ERK and the activities of NF-kB and HIF by leuciferase reporter activities. The effects were more potent in Coptis chinensis than its extracts. Since Coptis chinensis is a combination and is more potent in several effects than its main extracts, the future investigation needs to focus on the other extracts than the main extracts of Coptis chinensis for the anti-cancer effects. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。