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題名 | Lamotrigine Adjunctive Therapy in Children with Refractory Epilepsy: A Medical Center Study=樂命達附加性治療兒童頑固性癲癇--一醫學中心的研究 |
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作者姓名(中文) | 陳錫洲; 張開屏; 黃隸棟; 關尚勇; 許木嶺; 王志堅; | 書刊名 | 臺灣兒科醫學會雜誌 |
卷期 | 47:3 民95.05-06 |
頁次 | 頁123-126+159 |
分類號 | 415.932 |
關鍵詞 | 樂命達; 頑固性癲癇; 雷葛氏症候群; 胼肢體切開術; Lamotrigine; Refractory epilepsy; Lennox-Gastaut syndrome; Callosotomy; |
語文 | 英文(English) |
英文摘要 | The aim of this study was to investigate the effects of adjunctive lamotrigine (LTG) in refractory epilepsy in Taiwan, especially including patients who had undergone ineffective epileptic surgeries. Totally, 27 recruited children and adolescents with refractory epilepsy were treated with LTG addon therapy, but 23 were enrolled statistically during 2 years period trial. Ten of the 23 patients (43.5%), including 5 undergoing epileptic surgeries, before had a >50% reduction in seizure frequency. Surprisingly, LTG was found to have excellent response in six patients with Lennox-Gastaut Syndrome (LGS), 5 of whom had received anterior 2/3 callosotomy prior to the trial. Nonseizure related positive effects were presented in 3 patients, including greater alertness and attentiveness in 2 patients and improvement in mood in one patient. This open trial found that LTG was an effective add-on anti-epileptic drug (AED) in Taiwanese children and adolescents with refractory epilepsy and in cases with LGS even after ineffective callosotomy. |
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