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題 名 | Study on the Secondary Structure of Protein in Amide I Band from Human Colon Cancer Tissue by Fourier-Transform Infrared Spectroscopy=人類結腸癌組織蛋白質醯胺I帶二次結構之紅外線光譜研究 |
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作 者 | 陳英仁; 謝右文; 鄭奕帝; 廖繼洲; | 書刊名 | 長庚醫學 |
卷 期 | 24:9 2001.09[民90.09] |
頁 次 | 頁541-546 |
分類號 | 416.245 |
關鍵詞 | 結腸癌; 蛋白質二次結構; 醯胺I帶; 傅立葉紅外線光譜; Colon cancer; Protein secondary structure; Amide I; Fourier-transform infrared spectroscopy; |
語 文 | 英文(English) |
英文摘要 | BACKGROUND: Fourier-transform infrared spectroscopy (FT-IR) is a powerful tool for study of the secondary conformation of intact protein in biological tissues and for diagnosis of disease states. The purpose of this study is to utilize FT-IR as a diagnostic tool to estimate the secondary structure of amide I in normal and cancer tissue of human colon. METHODS: Pairs of tissue samples from colon cancer and histologically normal mucosa tissue 5-l0 cm from the tumor were obtained from a patient who underwent partial colectomy. In the present study we investigated the changes in the secondary structure of amide I of normal and malignant human colon tissue using FT-IR microspectroscopy with attenuated total reflectance. Secondary-derivative analysis relative to the original and curve-fitting analysis infrared spectra were also carried out. RESULTS: The conformational changes of the secondary structure of protein in normal and cancerous human colon tissue were (1) the composition of a-helixes increased in human cancerous colon tissue (15.30%) compared to normal colon tissue (11.72%); (2) b-sheets which were 46.8% in healthy tissue decreased to 30.71% in cancer tissue; (3) b-turns increased from 26.28% in normal tissue to 38.48% in cancer tissue; and (4) the composition of random coils was not significantly different between normal tissue (15.12%) and cancer tissue (15.51%). CONCLUSION: Our data demonstrate that protein in colon cancer displays abnormal FT-IR spectra. The conformational changes of the secondary structure of this protein in terms of a-helixes, b-sheets and b-turns were observed in normal and cancerous tissue from the same individual were compared. |
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