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題 名 | Effects of Colony-Stimulating Factors on the All-Trans Retinoic Acid-Induced Differentiation of Acute Promyelocytic Leukemic Cells=群落刺激因子對全反式維生素A酸(ATRA)誘導急性前骨髓性白血病細胞分化之影響 |
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作 者 | 徐會棋; 蔡玟蕙; 許敏玲; 何照洪; 王聲遠; | 書刊名 | 中華醫學雜誌 |
卷 期 | 57:2 1996.02[民85.02] |
頁 次 | 頁93-99 |
分類號 | 415.635 |
關鍵詞 | 顆粒球群落刺激因子; 顆粒球巨噬細胞群落刺激因子; 第三介白質; 分化; ATRA; Differentiation; G-CSF; GM-CSF; IL-3; |
語 文 | 英文(English) |
中文摘要 | 背景 NB4細胞是從一位具有t(l5;17)之急性前骨髓性白血病(APL)病患 所建立之細胞株,它以ATRA處理可以誘導細胞往顆粒性血球分化是研究細胞 分化很好的材料,本文報告我們研究群落刺激因子及ATRA在誘導NB4細胞分 化及增殖方面之互動情形。 方法 以Nitroblue tetrazolium(NBT)還原反應做為白血病細胞分化之功能指標, 以trypan blue排除試驗來檢查存活細胞數。 結果 NB4細胞增殖速度在以10-9 ATRA處理時會增加,但當ATRA濃度為 10-8M到10-7M時會逐漸受到抑制。控制組細胞培養五天沒有NBT-陽性細胞, 但10-7M ATRA可以誘導84%細胞為NBT-陽性。顆粒球群落刺激因子(G-CSF)單 獨無法誘導NB4細胞分化,但與ATRA(10-9M-10-6M)合用時可以加強後者之分 化作用。第三介白質(IL-3)及顆粒球巨噬細胞群落刺激因子(GM-CSF)本身亦無法 誘導NB4細胞分化,二者分別與ATRA合用時可以抑制後者所誘導之NBT反 應。IL-3及G-CSF合用時,對ATRA誘導分化之能力則無協同作用。 結論 我們的結果顯示G-CSF可以加強ATRA之分化能力,但IL-3及GM-CSF 則無,後續G-CSF合併ATRA之臨床效果仍需進一步研究。 |
英文摘要 | Background. NB4, a cell line derived from a patient with t(15;17) acute promyelocytic leukemia (APL) that undergoes granulocytic differentiation when treated with pharmacological doses of all-trans retinoic acid (ATRA), was used as a model for induction of differentiation. In this study, we examined the interaction of colony-stimulating factors (CSF) and ATRA in affecting the proliferation and differentiation of NB4 cells. Methods. Nitroblue tetrazolium (NBT) reduction was used as a functional marker of leukemia cell differentiation. The number of viable cells was counted by trypan blue exclusion test. Results. Proliferation of NB4 cells increased when exposed to 10-9M of ATRA, but reduced progressively when exposed to ATRA at the concentrations of 10-8M to 10-6M. After culture for 5 days, NBT-positive cell was not detectable in the control cultures with medium alone, but its percentage apparently increased to 84% at 10-7M ATRA. Granulocyte (G)-CSF per se had no effect on the granulocytic differentiation of NB4 cells, but it could enhance the NBT reduction when used in combination with various concentrations (10-9M - 10-6M) of ATRA. Interleukin (IL)-3 or granulocyte-macrophage-CSF (GM-CSF) alone also had no effect on the NBT reduction in NB4 cells. However, when combined with ATRA, both caused a slight suppression of NBT reduction. No synergistic effect was noted between IL-3 and G-CSF on the ATRA-induced granulocytic differentiation. Conclusions. G-CSF, but not IL-3 or GM-CSF, can enhance the differentiating activity of ATRA. Further investigations are necessary to evaluate its clinical use. |
本系統中英文摘要資訊取自各篇刊載內容。