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- Human Papillomavirus Type 5 Related Epidermodysplasia Verruciformis in a Patient with Systemic Lupus Erythematosus--Report of Two Cases and Review of the Literature
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題 名 | Human Papillomavirus Type 5 Related Epidermodysplasia Verruciformis in a Patient with Systemic Lupus Erythematosus--Report of Two Cases and Review of the Literature=與第五型人類乳突病毒相關的疣狀表皮增生不良於全身性紅斑性狼瘡的病人表現案例--病例報告與文獻回顧 |
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作 者 | 王昭欽; 蔡秀欣; 蔡宗憲; 李婉若; 王國憲; | 書刊名 | 中華皮膚科醫學雜誌 |
卷 期 | 24:4 民95.12 |
頁 次 | 頁278-284 |
分類號 | 415.7 |
關鍵詞 | 第五型人類乳突病毒; 疣狀表皮增生不良; 全身性紅斑性狼瘡; Epidermodysplasia verruciformis; Human papillomavirus; Systemic lupus erythematosus; Non-melanoma skin cancers; |
語 文 | 英文(English) |
中文摘要 | 疣狀表皮發育不良是一種罕見的皮膚疾病,它是因為宿主特別容易被一群特定的人類乳突病毒侵犯而引發廣泛性的感染。我們報告一個罹患全身性紅斑性狼瘡的四十二歲女性,首先在脖子上與前臂內側出現為數眾多的紅色扁平丘疹,其後三年漸次於臉上、脖子、前胸與背部長出大量的咖啡色斑。病理檢查在顆粒層與棘狀上皮層較表淺處可見到角質細胞增大且具有細胞質空泡狀的變化。據此,我們診斷疣狀表皮發育不良。此外,我們在病灶與周圍正常的皮膚均發現第五型人類乳突病毒的存在。我們分別使用銣雅各雷射、液態氮冷凍治療與Imiquimod來治療病人,三種方法於六個月後追蹤時均達到部分療效。除了報告此一特別病例,我們還回顧了疣狀表皮發育不良、與其相關的人類乳突病毒以及非黑色素瘤皮膚癌三者之問的關係。 |
英文摘要 | Epidermodysplasia verruciformis (EV) is a rare cutaneous human papilomavirus (HPV) infection characterized by an unusual susceptibility to a specific group of HPVs, so-called epidermodysplasia verruciformis associated human papillomaviruses (EV-HPVs). We herein report a 42-year-old women with a history of systemic lupus erythematosus (SLE) who initially showed multiple erythematous flat-topped papules on the neck and medial forearms and progressively developed numerous brownish macules on her face, neck, upper chest and back in the following three years. The histopathology revealed characteristic viral cytopathic changes in an acanthotic epidermis: multifocal enlarged keratinocytes with cytoplasmic vacuolization in granular layer and upper spinous layer. The diagnosis of EV was thus made. Besides, the presence of human papillomavirus type 5 (HPV 5) DNA was detected on the lesional and peri-lesional skin. The patient was then treated with different modalities including Erbium-YAG laser, cryotherapy with liquid nitrogen, and topical 5% imiquimod. Partial clearing of the lesions were observed by all these three modalities up to a 6-month period of follow-up. In addition, we make a review of the relationship between EV, EV-HPV and development of non-melanoma skin cancers (NMSCs). |
本系統中英文摘要資訊取自各篇刊載內容。