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題 名 | Effect of Chitosan on Plasma Lipids, Hepatic Lipids, and Fecal Bile Acid in Hamsters=幾丁聚醣對倉鼠血脂質、肝脂質及糞便膽酸的影響 |
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作 者 | 姚賢宗; 江孟燦; |
書刊名 | 藥物食品分析 |
卷 期 | 14:2 2006.06[民95.06] |
頁 次 | 頁183-189+221 |
分類號 | 414.52 |
關鍵詞 | 幾丁聚醣; 膽固醇; 脂蛋白; 倉鼠; Chitosan; Cholesterol; Lipoprotein; Hamsters; |
語 文 | 英文(English) |
中文摘要 | 幾丁聚糖是一種從幾丁質中所抽取出之天然物,它具有降低膽固醇作用,然而其降低血膽固醇的作用機制則較少被了解。本實驗設計以倉鼠為實驗動物,給予4%幾丁聚醣及高膽固醇 (0.2%) 飲食八週,探討幾丁聚醣對血漿脂蛋白糖固醇、肝臟膽固醇及糞便膽固醇與膽酸排出量的影響。實驗結果發現倉鼠攝食幾丁聚醣較纖維素明顯降低血漿總膽固醇 (TC) 、極低密度脂蛋白糖固醇 (YLOL-C) 及低密度脂蛋白膽固醇 (LDL-C) 含量。幾丁聚醣雖不影響高密度脂蛋白糖固醇 (HOL-C) 含量,但會提高HOL/TC比值。此外,幾丁聚醣不會改變血漿三酸甘油路及膽固醇酯運送蛋白 (CETP) 活性。幾丁聚醣降低倉鼠肝臟膽固醇主要是膽固醇酯的部分,而糞便膽固醇及膽酸排出量亦會明顯增加。由本實驗結果推測幾丁聚醣降低倉鼠膽固醇作用可能主要與增加糞便膽固醇與膽酸排出量有關。 |
英文摘要 | Chitosan is a natural product derived from chitin that possesses hypocholesterolemic properties. However, the mechanism of its cholesterol-lowering effect is still unclear. This study was designed to investigate the effect of chitosan on plasma lipoprotein cholesterol, liver cholesterol and fecal excretion of cholesterol and bile acid in hamsters. Hamsters were fed a high-cholesterol (0.2%) diet containing 4% cellulose (CE) or 4% chitosan (CS) for eight weeks. The hamsters fed the CS diet had significantly lowered plasma total cholesterol (TC), very low-density lipoprotein cholesterol (VLDL-C) and low-density lipoprotein cholesterol (LDL-C) than those fed the CE diet. CS had no effect on high-density lipoprotein cholesterol (HDL-C) level, but higher ratio of HDL-C to TC was observed in hamsters fed the CS diet when compared with those fed with the CE diet. In addition, CS did not change plasma triglyceride and cholesteryl ester transfer protein (CETP) activity. Hepatic cholesterol contents were significantly lower in hamsters fed CS primarily due to the reduced accumulation of the esterified cholesterol. Fecal excretion of cholesterol and bile acid were significantly increased in hamsters after the CS treatment. Results from this study suggest that the cholesterol-lowering effect of CS may be primarily related to an increase in fecal excretion of cholesterol and bile acid in hamsters. |