查詢結果分析
來源資料
頁籤選單縮合
題名 | 血品照射儀的劑量分佈評估=The Evaluation of Dose Distribution for Blood Irradiator |
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作者 | 張東浩; 盧勇發; 陳苑蓉; 林招膨; 丁健益; | 書刊名 | 臺灣應用輻射與同位素雜誌 |
卷期 | 2:1 民95.03 |
頁次 | 頁47-52 |
分類號 | 414.93 |
關鍵詞 | 血品照射儀; 移植反宿主疾病; 化學氣相沉積鑽石薄膜; 樣本容器; 空間劑量分佈; Graft-versus-host disease; GVHD; Blood irradiator; CVD diamond film; Sample container; Dose distribution; |
語文 | 中文(Chinese) |
中文摘要 | 近年來輸血後移植反宿主疾病(GVHD)是骨髓移植和器官移植最多致死的合併症。所以,要輸給免疫缺乏症病人之各種血品,必須先施以15~50Gy輻射照射劑量,破壞血品中淋巴球的免疫能力,以避免GVHD的發生。由於國內,外漸漸的在血品照射方面,以可直接放置於血庫中的137Cs血品照射儀取代直線加速器;因此對於137Cs血品照射儀的照射劑量品質、劑量分布,建立血品照射劑量檢測品質控制標準,確保病患輸血安全以及對操作人員的劑量評估,便顯得刻不容緩。 對於以化學氣相沉積法(Chemical Vapour Deposition, CVD)產生的鑽石薄膜,其熱發光的輝光曲線備又其動力學的特性,已有多位研究人員發表其研究成果。本文使用CVD鑽石薄膜作為血品照射儀的輻射劑量量測工具,量測MDS Nordion’s Gammacell (GC 1000Elite)血品照射儀中樣本容器內中心點及參考點的絕對劑量,以及樣本容器(Sampel container)體積內劑量分佈之情形。 由分析結果顯示CVD鑽石薄膜的吸收劑量回應曲線在高劑量區(5-30Gy)呈現線性(R-square為0.9707);CVD鑽石薄膜量測不確定度在5%內。所以CVD鑽石薄膜非常適用於量測血品照射儀(照射劑量25Gy)的輻射劑量分佈。樣本容器(Sample container)體積內劑量分佈平均吸收劑量為29.79±5.46Gy;樣本容器中心點吸收量為29Gy。均高於原廠設定值25Gy約13.6%。而且在實際量測樣本容器空間劑量分佈的不均勻度為16%,與原廠的劑量分佈結果(劑量分佈的不均勻度為19%)相近。低劑量區集中在樣品容器的中下區域,而高劑量區集中在樣品容器的兩側區域。 |
英文摘要 | Recently, Graft-versus-Host Disease (GVHD) is a well-know complication of allogeneic bone marrow transplantation and is increasingly being recognized after solid-organ transplantation and transfusion. The radiation dose currently accepted to prevent GVHD is typically 15Gy to 50Gy. Blood irradiators are now in widespread use in the blood irradiation rather than LINACs because their security and convenient. Therefore, evaluated te dosimetry of blood irradiator is very important to confirm the safety of patients. Many research workers have investigated the glow curve and dynamic of CVD diamond film fabricated with chemical vapor deposition methods (CVD method). This work is to study CVD diamond as a tool for blood irradiator dosimetry. We were measured the absorption dose distribution and spatial dose distribution of sample container of blood irradiator (GC 1000 Elite). Results of experiment show that the response of absolute dose was display linearity (R-squire 0.9707) for CVD diamond in high dose region (5-30Gy), and measurement uncertainty is about 5%. The CVD diamond is a practical material for blood irradiator measurements. The average absorbed dose is abot 29.79±5.46Gy and the center absorbed dose is about 29Gy of sample container of blood irradiator. |
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