查詢結果分析
來源資料
頁籤選單縮合
題名 | Magnolol Modifies the Cytokine Response after Sublethal Hemorrhage=厚朴醇改變亞致死性出血後細胞激素之反應 |
---|---|
作者姓名(中文) | 施信嶔; 吳哲侃; 黃睦瞬; 黃俊一; 李建賢; 黃燦龍; | 書刊名 | 臺灣外科醫學會雜誌 |
卷期 | 39:1 民95.01-02 |
頁次 | 頁1-8 |
分類號 | 414.5 |
關鍵詞 | 厚朴醇; Magnolol; 抗氧化劑; 亞致死性出血後細胞激素; Sublethal hemorrhage; Endotoxin tolerance; Cytokine; Antioxidant; |
語文 | 英文(English) |
中文摘要 | 厚朴醇(magnolol)是一種強抗氧化劑,利用此特性,厚朴醇可能影響亞致死性出血後細胞激素之釋放。大白鼠隨機分三組。控制組接受假手術和溶劑處理;非治療組接受亞致死性出血和溶劑處理;治療組接受亞致死性出血和厚朴醇治療。所有動物在二十四小時後接受致死性內毒素注射。在亞致死性出血和內毒素注射後,測量血漿中甲型腫瘤壞死因子(TNF-alpha)和第十型細胞间素(IL-10)之濃度,以及肺臟脂肪過氧化(lipid peroxidation)和超氧歧化酵素(SOD)活動性。亞致死性出血後,血漿中甲型腫瘤壞死因子,在治療組和非治療組皆增加;但在治療組則比非治療組有意義的降低。內毒素注射後,治療組和非治療組甲型腫瘤壞死因子皆比控制組為低。血漿中第十型細胞激素,在治療組比非治療組則有意義的增加。脂肪過氧化和超氧歧化酵素活動性在非治療組增加。厚朴醇抑制脂肪過氧化但是對超氧歧化酵素活動性則無影響。內毒素注射後,控制組有較高的脂肪過氧化。存活率分析發現,治療組與非治療組並無顯著意義的差別。厚朴醇改變亞致死性出血後,細胞激素和氧化功能;雖然厚朴醇不顯著影響隨後大白鼠內毒素注射之存活結果,但可增加亞致死性出血後第十型細胞間素和保存超氧歧化酵素活動性 |
英文摘要 | Objective: This study examined whether cytokine response accompanied by sublethal hemorrhage (SLH) might be modified by treatment with magnolol. Methods: Rats were randomly segregated into three experimental groups. The control group rats received sham-operations and vehicle treatment. The untreated group rats received SLH and vehicle treatment. The treated group rats received SLH and magnolol treatment. All animals were subjected to subsequent lethal endotoxin challenge 24 hours later. Plasma TNF-alpha and IL-l0 levels, lipid peroxidation, and superoxide dismutase (SOD) activity in the lung were measured following SLU or endotoxin challenge. Results: Plasma TNF-alpha increased after SLH in both the treated and untreated groups, whereas a significant lower level was noted in the treated group compared with the untreated group. After endotoxin sepsis, blunting of the TNF-alpha levels were found in both the treated and untreated groups. The plasma IL-l0 level increased significantly in the treated group compared with that in the untreated and control groups. Lipid peroxidation and SOD activity increased after SLH in the untreated group. Magnolol suppressed the lipid peroxidation but not the SOD activity. After endotoxin, lipid peroxidation was higher in the control group compared with that in the treated and untreated groups. Survival analysis showed that outcome was not different between the treated and untreated groups. Conclusion: Magnolol modifies the response of cytokines and decreases their oxidative activity after SLH. Magnolol increases IL-l0 response and preserves SOD activity after SLH, although the final outcome after subsequent endotoxin challenge is not altered significantly. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。