查詢結果分析
來源資料
相關文獻
- Hypolipidemic Effects of Inulin and Synthetic Oligofructose in Balb/c Mice
- Blood Lipid Distrbution in Patients with Newly-Diagnosed, Non-Insulin-Dependent Diabetes Mellitus
- Cholesterol Nucleation in Supersaturated Model Bile of Different Total Lipid Concentrations
- Atorvastatin (Lipitor[feb9])--可以對抗膽固醇與三酸甘油脂的新藥
- 高脂血症的運動處方
- 補陽還五湯降血脂作用
- 不同種類之蛋白質對血清脂質代謝之影響
- Prevalence of Hypercholesterolemia and Its Related Factors in Middle-aged Taiwanese Adults -- A Hospital-based Study
- 心血管疾病預測指標與運動時心跳率之關係
- 食用橄欖油對血脂質濃度影響之研究
頁籤選單縮合
題名 | Hypolipidemic Effects of Inulin and Synthetic Oligofructose in Balb/c Mice=菊糖及生技果寡醣對小鼠脂質代謝之影響 |
---|---|
作 者 | 陳曉鈴; 向怡曄; 吳文慈; 林孟萱; | 書刊名 | 中華民國營養學會雜誌 |
卷期 | 30:2 民94.09 |
頁次 | 頁99-107 |
分類號 | 411.38 |
關鍵詞 | 菊糖; 生技果寡醣; 膽固醇; 三酸甘油脂; 膽酸; 短鏈脂肪酸; Inulin; Oligofructose; Cholesterol; Triacylglycerol; Bile acid; Short-chain fatty acid; |
語文 | 英文(English) |
中文摘要 | 本實驗主旨在探討菊糖及生技果寡醣對Balb/c小鼠之降血脂功效,以及這些作用是否與糞便脂質排出以及糞便短鏈脂肪酸濃度有關。七週齡小鼠隨機分為三組,各餵飼含有5%纖維素、菊糖或果寡醣之AIN-93G飼料三週,並於第18-20天收集糞便以分析中性固醇、膽酸、粗脂以及短鏈脂肪酸。實驗結束後,收集血液及肝臟以分析膽固醇、三酸甘油脂以及磷脂質。結果顯示,與纖維素相較,菊糖或果寡醣顯著降低血膽固醇濃度以及三酸甘油脂濃度。各組之肝臟膽固醇及磷脂質含量無顯著差異,但是果寡醣顯著降低肝臟三酸甘油脂含量。與纖維素相較,菊糖使小鼠每日糞便中性固醇排出量提高約1.5倍,而果寡醣則提高約0.6倍;菊糖及果寡醣各提高小鼠每日糞便膽酸排出量約一倍;菊糖及果寡醣亦顯著降低外表脂質吸收率。在糞便短鏈脂肪酸濃度方面,各組之乙酸濃度無顯著差異,然而菊糖及果寡醣皆提高總短鏈脂肪酸濃度、丙酸濃度以及丙酸之比例。因此本實驗建議菊糖及生技果寡醣之降血脂效應與糞便中脂質之排出以及其發酵產物有關。 |
英文摘要 | The aim of this study was to investigate the modulatory effects of inulin and synthetic oligofructose (OFS) on blood lipid levels, and whether these effects are associated with fecal excretion of lipids and fecal short-chain fatty acids (SCFAs) in Balb/c mice. Seven-week-old mice were fed modified AIN-93 diets containing 5% cellulose, inulin, or OFS for 3 weeks. The cholesterol, triacylglycerol, and phospholipids levels in the plasma and liver were determined. Feces collected during days 18~20 was analyzed for neutral steroid, bile acid, crude fat, and SCFAs. Both inulin and OFS significantly decreased the plasma cholesterol and triacylglycerol levels as compared with cellulose. Most of the hepatic lipid contents were similar across groups, except that OFS significantly reduced the hepatic triacylglycerol content. Inulin elevated the daily neutral steroid excretion by ~1.5-fold while OFS slightly increased the neutral steroid excretion by 0.6-fold, as compared with cellulose. Inulin and OFS similarly caused a 1-fold increases in fecal bile acid excretion. Furthermore, the apparent fat absorption in mice fed inulin and OFS diets were similar, 78.7%(5.3% and 77.6% (4.7%, respectively, which were significantly lower than that of mice fed the cellulose diet, 88.7% (5.9%. The fecal acetate concentration did not significantly differ among groups. However, inulin and OFS significantly promoted the concentration and proportion of propionate in the feces. In conclusion, increased fecal excretion of steroids, reduced fat absorption, and increased production of propionate may mediate the hypolipidemic effects of inulin and OFS in Balb/c mice. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。