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| 題 名 | Effect of Omeprazole in One Patient with Peptic Ulcer=Omeprazole對十二指腸潰瘍患者之影響 |
|---|---|
| 作 者 | 賴啟賢; 賴昱良; 林君榮; | 書刊名 | 中臺灣醫學科學雜誌 |
| 卷 期 | 10:2 2005.06[民94.06] |
| 頁 次 | 頁107-111 |
| 分類號 | 418.24 |
| 關鍵詞 | 基因型; 質子幫浦抑制劑; CYP2C19; Genotype; Proton pump inhibitors; |
| 語 文 | 英文(English) |
| 中文摘要 | 為瞭解因十二指腸潰瘍必須服用質子幫浦抑制劑患者,引起肝功能異常後,其體內位於細胞內質綱中群含血基質的Cytochrome P450酵素系統,CYP2C19之基因多型性代謝情形,及其影響病患將來治療預後演變之臨床意義。故本研究病例即為長期使用Omeprazole治療後之十二指腸潰瘍病患,且臨床上並發現到有肝功能異常現象,此病例之血漿中DNA測定發出其CYP2C19為快速代謝者,故可能於一般治療劑量下Omeprazole於此病例血漿內濃度較低,導致臨床上療效不佳,但是否此類PPI藥物對此病例之CYP2C19基因型代謝系統有直接產生抑制破壞作用,而產生臨床上肝指數升高現象,則尚待更進一步研究探討。 |
| 英文摘要 | Omeprazole, a proton pump inhibitor widely used in the treatment of reflux esophagitis and peptic ulcer, is metabolized by S-mephenytoin 4-hydroxylase (CYP2C19), which is encoded on Cytochrome P450 in the liver. Genetic polymorphisms identified for CYP2C19 include the extensive metabolizer (EM), intermitted metabolizer (TM) and poor metabolizer (PM). We report a patient with reflux esophagitis and peptic ulcer who complained of persistent epigastric pain after taking omeprazole 40 mg per day for six weeks. The CYP2C19 genotype status for 2 mutations associated with the extensive metabolizer phenotype of this patient was determined by a polymerase chain reaction-restriction fragment length poly morphism method. We found that this patient exhibited the CYP2CI9 extensive metabolizer polymorphism. However, the relationship between genetic polymorphisms of CYP2C19 and clinical usage of proton pump inhibitors is still unclear. |
本系統中英文摘要資訊取自各篇刊載內容。