查詢結果分析
相關文獻
- 評估Alginate/Pluronic複合配方做為原位成膠輸送眼藥用載體之可行性
- 輸送眼藥用之原位成膠PAA、Gelrite及PAA/Gelrite系統流變行為之探討
- 實驗用囓齒動物飼料配方AIN-93G之鐵質生體可用率
- 市售高鈣高鐵奶粉之鐵質生體可用率
- 口服Ketorolac生體可用率研究
- 加工方法對糙米及黃豆製品鐵質生體可利用率之影響
- Relative Bioavailability Study of Cefuroxime Axetil Tablets
- HPLC Determination of 9,10-Anthraquinone-2-Carboxylic Acid in Serum and Its Application to Pharmacokinetic Study
- Pharmacokinetics and Bioequivalent Study of Generic Fluoxetine Capsules Preparation
- Comparative Pharmacokinetics of Two Atenolol Products
頁籤選單縮合
題名 | 評估Alginate/Pluronic複合配方做為原位成膠輸送眼藥用載體之可行性=Evaluation of Using Alginate/Pluronic Solution as an In Situ Gelling System for Ophthalmic Drug Delivery |
---|---|
作者 | 蔣文達; 林鴻儒; 汪文忠; 郭俊榕; 宋國峻; 李進送; 王翠霜; 施佩禎; Chang, Wen-da; Lin, Hong-ru; Vong, Wen-jong; Kuo, Chun-jung; Sung, K. C.; Li, Chen-shun; Wang, Tsui-shuang; Shih, Pei-jen; |
期刊 | 嘉南學報 |
出版日期 | 20021100 |
卷期 | 28 2002.11[民91.11] |
頁次 | 頁196-207 |
分類號 | 418.2323 |
語文 | chi |
關鍵詞 | 生體可用率; 原位成膠; 相轉移流變行為; 眼藥輸送; Bioavailability; In situ gel formation; Phase transition; Rheological behavior; Ophthalmic delivery system; |
中文摘要 | 一般市面用液體眼藥製劑常因滴入眼睛時,受到經常性的淚液分泌及鼻淚管的快速排液,因此呈現很低的生體可用率(Bioavailability),此缺點可用原位成膠(In-site gel formation)輸送系統來加以改善。本文分別製備Pluronic、Alginate及Pluronic/Alginate高分子溶液做為輸送眼睛載體,藉由這些載體在非生理狀態轉變到生理狀態時會產生相轉移(Phase transition),來延長藥劑在前角膜的滯留時間,進而增加眼精的生體可用率。本文首先尋找三種系統之最適合配方,發現14% Pluronic、2% Alginate與14% Pluronic/0.1% Alginate為在單獨配方或複合配方中最適合輸送眼藥之系統,由流變行為(Rheological behavior)觀點得知複合配方之凝膠強度優於單獨配方。本文並將治療青光眼的藥劑(Pilocarpine hydrochloride)加入各種配方內,探討藥物在生理狀態下對配方之影響,結果發現藥物會使單獨配成之凝膠強度下降,而複合配方之凝膠強度則反而增強。由此更加證明14% Pluronic/0.1 Alginate複合配方優於單獨配方,可做為輸送眼藥(Ophthalmic delivery)的原位成膠載體,進而提高眼睛的生體可用率。本實驗目前正在進行活體外(In vivo)與活體內(In vitro)試驗,以評估此輸送系統之藥理反應(Pharmacological response)。 |
英文摘要 | The commercialized liquid ophthalmic formulation is eliminate from the precorneal area immediately upon instillation because of lacrimal secretion and nasolacrimal drainage. This results in very low ocular bioavailability. The problem can be conqurered by in situ gelling system for ophthalmic drug delivery. In this study, a series of polymer solutions including Pluronic, Alginate, and Pluronic/Alginate solutions were prepared and used as in situ gelling vehicles for ophthalmic drug delivery. The phase transition of these vehicles occurs once their exposure environment is switched from non-physiological to physiological condition. Which can prolong the residence times of the drug in the eye and improve the ocular bioavailability. It was found that the optimum concentrations for the in site gel system were 14% Pluronic, 2% Alginate, and 14% Pluronic/0.1% Alginate, respectively. From rheological behavior, it demonstrated that the gel strength of Pluronic/Alginate mixture was greater than that of Pluronic or Alginate solutions alone. The effects of pilocarpine hydrochloride on the rheological behaviors of the polymer solutions were also investigated in this study. It was found the gel strength of the drug-containing individual polymer solution was decreased, but that of the mixture was increased. This further indicates that the rheological behavior of the 14% Pluronic/0.1% Alginate solution was better than that that of Pluronic or Alginate solutions alone. The results demonstrated that this polymer mixture can be used as an in situ gelling vehicle to enhance the ocular bioavailability. In addition, the study of in vitro pilocarpine release and vivo pilocarpine pharmacological response of various drug-containing polymer solutions are carrying on in our lab. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。