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| 題 名 | The Anti-Apoptotic Bcl-2 Homologue: A1=B細胞淋巴瘤相關蛋白:A1 |
|---|---|
| 作 者 | 劉劍英; 郭漢彬; | 書刊名 | 胸腔醫學 |
| 卷 期 | 17:2 2002.06[民91.06] |
| 頁 次 | 頁89-105 |
| 分類號 | 415.114 |
| 關鍵詞 | 細胞生理死亡; Bcl-2蛋白質群; 粒腺體; 核因子NF-kB; Apoptosis; Bcl-2; Al; Mitochondria; Nuclear factor kB; |
| 語 文 | 英文(English) |
| 中文摘要 | 細胞生理死亡在維持組織生理平衡上具有重要角色。Bcl-2蛋白質群和Caspase脢系統、粒腺體、以及以細胞核為標的之細胞生理死亡因子群已經被認為是細胞內細胞生理死亡傳訊路徑的基本組成。A1為抗細胞生理死亡Bcl-2同類蛋白之一員,最初被認為是具血球生成系統專一性的早發反應性基因,與淋巴系和骨髓系血球生成及分化有關。最近的研究更進一步的發現A1對胚胎發育具有重要角色並可能調控血管內皮細胞之發炎反應。A1可能做用於粒腺體而延緩細胞死亡,並且與核因子NF-kB有交互作用。隨著在鼠類發現多重基因表現以及至今仍無法製造出抗人類A1蛋白之專一抗體、大部份與A1有關之生物機能的分子機轉仍不明白。這篇文獻回顧介紹了A1基因的發現、A1蛋白與其它Bc1-2蛋白結構的相似處和生物機能的相異處、以及有關A1研究最近的進展。以條件調控基因表現為模式的研究將有助於進一步闡明A1在組織發展和細胞生物學上的確切功能。 |
| 英文摘要 | Apoptosis is an important physiological process for maintaining tissue homeostasis. Proteins of the Bcl-2 family, together with the caspase system, mitochondria, and nucleus-targeting factors, have been considered essential components of the intracellular apoptotic signaling pathways. A1, as a member of the anti-apoptotic Bcl-2 homologues, was first identified as a hematopoietic-specific early-response gene with a role in the development and differentiation of lymphoid and myeloid lineages. Recent studies have further demonstrated the important role of A1 in embryonic development and in modulating the inflammatory response in endothelial cells. A1 may function on mitochondria to delay cell death and interact with nuclear factor-kB signaling pathways. With the findings of multiple gene duplication and the expression of murine A1, as well as the difficulty of raising a specific anti-human A1 antibody to date, most of the knowledge regarding the molecular mechanisms of the biological function of A1 is not clear. This review introduces the identification of A1, the similarity of protein structure with and the functional differences of A1 from other Bcl-2 members, as well as recent progress in A1 research. Further study using conditional gene-engineered models will be helpful to clarify the exact role of A1 in cell functions and tissue development. |
本系統中英文摘要資訊取自各篇刊載內容。