查詢結果分析
來源資料
相關文獻
- Genetic Studies in Acute Lymphoblastic Leukemia
- 認知風格、認知策略、遺傳學知識與遺傳學解題之研究
- 臺灣人第一型糖尿病之遺傳學研究
- The Genetics and Embryology of Taiwan Fir (Abies Kawakamii (Hayata) Ito)
- 物種保育的遺傳學觀點
- 遺傳學解題歷程模式的建構與解題測驗的發展
- Developmental Biology: Frontiers for Clinical Genetics
- Development of Acute Lymphoblastic Leukemia in a Child after Treatment of Langerhans Cell Histiocytosis: Report of One Case
- 神經學之最新發展(2):杭丁頓舞蹈症(Huntington's Chorea)之研究發展--神經遺傳學之簡介
- Cytogenetics: From Aneuploidy to Polymorphism
頁籤選單縮合
題名 | Genetic Studies in Acute Lymphoblastic Leukemia=急性淋巴性白血病之遺傳學研究 |
---|---|
作者姓名(中文) | 裴正康; | 書刊名 | 臺灣兒科醫學會雜誌 |
卷期 | 41:6 民89.11-12 |
頁次 | 頁303-307 |
分類號 | 415.635 |
關鍵詞 | 急性淋巴性白血病; 遺傳學; Acute lymphoblastic leukemia; Genetic abnormalities; Minimal residual leukemia; Pharmacogenetics; Philadelphia chromosome; |
語文 | 英文(English) |
英文摘要 | As the long-term event-free survival rate in children with acute lymphoblastic leukemia approaches 80%, emphasis is being placed on risk-directed therapy to prevent over-or undertreatment. It has become apparent that risk assignment based on primary genetic abnormalities is inadequate by itself, and that measurement of early responses to therapy and the extent of minimal residual disease is needed to improve the accuracy of risk classification. Studies to identify genetic polymorphisms with pharmacokinetic and pharmacodynamic significance promise to enhance the discovery of new drugs and to optimize chemotherapy. Recent successes in directing therapy to specific genetic abnormalities demonstrate the feasibility of molecular medicine for the childhood leukemias, and predict the development of highly effective drug regimens with minimal toxicity against normal hematopoietic cells. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。