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題 名 | Development of Acute Lymphoblastic Leukemia in a Child after Treatment of Langerhans Cell Histiocytosis: Report of One Case=藍罕氏組織細胞增生症治療後併發急性淋巴性白血病:一病例報告 |
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作 者 | 吳家華; 盧孟佑; 林凱信; 周獻堂; 林東燦; | 書刊名 | 臺灣兒科醫學會雜誌 |
卷 期 | 40:6 民88.11-12 |
頁 次 | 頁441-442+468 |
分類號 | 417.5515 |
關鍵詞 | 藍罕氏組織細胞增生症; 急性淋巴性白血病; Langerhans cell histiocytosis; Acute lymphoblastic leukemia; |
語 文 | 英文(English) |
中文摘要 | 藍罕氏組織細胞增生症(Langerhans cell histiocytosis)是一種非惡性的兒科 疾病。雖然,藍罕氏組織細胞增生症和續發性惡性腫瘤間相關性至今仍不清楚,不過已有數 個這樣的病例被報告過。在此,我們要提出一位病例。這位小女孩一開始在其左側股骨,被 發現有一處局限性的蝕骨性病灶,經確定是藍罕氏組織細胞增生症。於是接受了局部的清創 術與化學治療達八個月,而 X 光片則顯示病灶已完全治癒。 然而,這位小女孩在六年後卻 被發現罹患了急性淋巴性白血病。我們回顧了過去的文獻,截至目前為止,包括我們的病例 在內,只有五位藍罕氏組織細胞增生症的小孩子,後來也罹患了急性淋巴性白血病。因此藍 罕氏組織細胞增生症和惡性腫瘤間相關性,究竟藍罕氏組織細胞增生症本身疾病的一種自然 過程? 還是與治癒有關才引起的續發性惡性腫瘤? 可能需要更多的病例來分析。不管如何, 此應為臺灣第一位病例報告。 |
英文摘要 | Langerhans cell histiocytosis (LCH) is a group of poorly understood disorders. To our knowledge, LCH is a non-malignant disorder. The association of LCH with a secondary neoplasm has not been well assessed, however, a few cases have been reported. We report a case of LCH, a localized osteolytic lesion over metaphysis of left femur, who was treated with local curettage and chemotherapy with vincristine, prednislone and 6-mercaptopiirine (6-MP) for eight months from end of 199] to August, 1992. Six years later, she had acute lymphoblastic leukemia (ALL) in 1998. In review of current literature, only 5 cases of LCH. including our case, have preceded ALL. The possible association, a reactive process or a therapy-related process, between LCH and acute leukemia is still unclear at present and needs to he explored by more studies in the future. |
本系統中英文摘要資訊取自各篇刊載內容。